@prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . @prefix prodotto: . unitaDiPersonaleInterno:MATRICOLA660 pubblicazioni:autoreCNRDi prodotto:ID12365 . @prefix prodottidellaricerca: . @prefix istituto: . istituto:CDS014 prodottidellaricerca:prodotto prodotto:ID12365 . unitaDiPersonaleInterno:MATRICOLA8694 pubblicazioni:autoreCNRDi prodotto:ID12365 . @prefix modulo: . modulo:ID2564 prodottidellaricerca:prodotto prodotto:ID12365 . @prefix rdf: . @prefix retescientifica: . prodotto:ID12365 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1101 . @prefix rdfs: . prodotto:ID12365 rdfs:label "Effects of live and inactivated VSL#3 probiotic preparations in the modulation of in vitro and in vivo allergen-induced Th2 responses (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID12365 pubblicazioni:anno "2009-01-01T00:00:00+01:00"^^xsd:gYear ; pubblicazioni:doi "10.1159/000218116"^^xsd:string . @prefix skos: . prodotto:ID12365 skos:altLabel "
Mastrangeli G 1), Corinti S 1) , Butteroni C 1), Afferni C 1), Bonura A 2), Boirivant M 1), Colombo P 2), and Di Felice G 1). (2009)
Effects of live and inactivated VSL#3 probiotic preparations in the modulation of in vitro and in vivo allergen-induced Th2 responses
in International archives of allergy and immunology
"^^rdf:HTML ; pubblicazioni:autori "Mastrangeli G 1), Corinti S 1) , Butteroni C 1), Afferni C 1), Bonura A 2), Boirivant M 1), Colombo P 2), and Di Felice G 1)."^^xsd:string ; pubblicazioni:paginaInizio "133"^^xsd:string ; pubblicazioni:paginaFine "143"^^xsd:string ; pubblicazioni:numeroVolume "150"^^xsd:string . @prefix ns11: . prodotto:ID12365 pubblicazioni:rivista ns11:ID252671 ; pubblicazioni:pagineTotali "10"^^xsd:string ; pubblicazioni:numeroFascicolo "2"^^xsd:string ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "1) Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanit\u00E0, Rome,\n2) Istituto di Biomedicina ed Immunologia Molecolare 'Alberto Monroy', Consiglio Nazionale delle Ricerche, Palermo, Italy"^^xsd:string ; pubblicazioni:titolo "Effects of live and inactivated VSL#3 probiotic preparations in the modulation of in vitro and in vivo allergen-induced Th2 responses"^^xsd:string ; prodottidellaricerca:abstract "Background: The immunological mechanisms responsiblefor the immunomodulatory and anti-allergic effects of probiotic\nbacteria are still poorly defined. The combined effects of mixtures of different species of probiotic bacteria have\nbeen explored only in part. The present study describes the immunomodulatory activity of the VSL#3 probiotic preparation\nin in vitro and in vivo systems. Methods: The activation and cytokine production by in vitro probiotic-stimulated\nbone-marrow dendritic cells (BM-DCs) and spleen cells isolated from na\u00EFve or Par j 1-sensitized mice were investigated.\nMice were intranasally administered a sonicate preparation of VSL#3 before immunization with rPar j 1. Serum antibody\nlevels and cytokine expression in the lung were determined. Results: Both live and sonicated VSL#3 preparations induced\nmaturation and cytokine production by BM-DCs. Cytokine production by spleen cells from na\u00EFve or Par j 1-sensitized mice was modulated by the probiotic preparations towards a Treg/Th0 profile, characterized by increased IL-10 and IFN-g ? production. In vivo prophylactic treatment with VSL#3 induced a significant reduction of serum specific IgG1. At lung level, VSL#3 pre-treatment remarkably reduced IL-13 and IL-4 mRNA expression and increased IL-10 expression.\nConclusions: The VSL#3 preparations have not only the capacity to bias primary immune responses towards a Treg/ Th0-type profile, but also to modify in the same way the functional characteristics of established in vitro Th2 responses.\nIn vivo studies on a mouse model of Par j 1 sensitization indicate that the prophylactic intranasal treatment with probiotic\nbacteria is able to modulate the development of Th2-biased responses."@en ; prodottidellaricerca:prodottoDi istituto:CDS014 , modulo:ID2564 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA660 , unitaDiPersonaleInterno:MATRICOLA8694 . @prefix parolechiave: . prodotto:ID12365 parolechiave:insiemeDiParoleChiave . ns11:ID252671 pubblicazioni:rivistaDi prodotto:ID12365 . parolechiave:insiemeDiParoleChiaveDi prodotto:ID12365 .