@prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . @prefix prodotto: . unitaDiPersonaleInterno:MATRICOLA802 pubblicazioni:autoreCNRDi prodotto:ID12087 . @prefix prodottidellaricerca: . @prefix istituto: . istituto:CDS014 prodottidellaricerca:prodotto prodotto:ID12087 . unitaDiPersonaleInterno:MATRICOLA8474 pubblicazioni:autoreCNRDi prodotto:ID12087 . @prefix modulo: . modulo:ID5465 prodottidellaricerca:prodotto prodotto:ID12087 . modulo:ID2669 prodottidellaricerca:prodotto prodotto:ID12087 . @prefix rdf: . @prefix retescientifica: . prodotto:ID12087 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1101 . @prefix rdfs: . prodotto:ID12087 rdfs:label "CD40 ligation protects bronchial epithelium against oxidant-induced caspase-independent cell death (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID12087 pubblicazioni:anno "2006-01-01T00:00:00+01:00"^^xsd:gYear ; pubblicazioni:doi "10.1165/rcmb.2005-0433OC"^^xsd:string . @prefix skos: . prodotto:ID12087 skos:altLabel "
Merendino AM, 1; Bucchieri F, 2; Gagliardo R, 3; Daryadel A, 4; Pompeo F, 3; Chiappara G, 3; Santagata R, 1; Bellia V, 1; David S, 2; Farina F, 2; Davies DE, 5; Simon HU, 4; Vignola AM 1, 3. (2006)
CD40 ligation protects bronchial epithelium against oxidant-induced caspase-independent cell death
in American journal of respiratory cell and molecular biology
"^^rdf:HTML ; pubblicazioni:autori "Merendino AM, 1; Bucchieri F, 2; Gagliardo R, 3; Daryadel A, 4; Pompeo F, 3; Chiappara G, 3; Santagata R, 1; Bellia V, 1; David S, 2; Farina F, 2; Davies DE, 5; Simon HU, 4; Vignola AM 1, 3."^^xsd:string ; pubblicazioni:paginaInizio "155"^^xsd:string ; pubblicazioni:paginaFine "164"^^xsd:string ; pubblicazioni:numeroVolume "35"^^xsd:string . @prefix ns11: . prodotto:ID12087 pubblicazioni:rivista ns11:ID510942 ; pubblicazioni:numeroFascicolo "2"^^xsd:string ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "1 Department of Medicine, Pneumology, Physiology, and Human Nutrition;\n2 Department of Experimental Medicine, Section of Human Anatomy, Universita` di Palermo, Palermo; \n3 Institute of Biomedicine and Molecular Immunology (IBIM), Italian National Research Council, Palermo, Italy;\n4 Department of Pharmacology, University of Bern, Bern, Switzerland\n5 Division of Infection, Inflammation, and Repair, University of Southampton, United Kingdom;"^^xsd:string ; pubblicazioni:titolo "CD40 ligation protects bronchial epithelium against oxidant-induced caspase-independent cell death"^^xsd:string ; prodottidellaricerca:abstract "CD40 and its ligand regulate pleiotropic biological responses, including\ncell proliferation, differentiation, and apoptosis. In many\ninflammatory lung diseases, tissue damage by environmental or\nendogenous oxidants plays a major role in disease pathogenesis.\nAs the epithelial barrier is a major target for these oxidants, we\npostulated that CD40, the expression of which is increased in\nasthma, plays a role in the regulation of apoptosis of bronchial\nepithelial cells exposed to oxidants. Using 16HBE 14o? cells exposed\nto oxidant stress, we found that ligation of CD40 (induced\nby G28-5 monoclonal antibodies) enhanced cell survival and increased\nthe number of cells in G2/M (interphase between DNA\nsynthesis and mitosis) of the cell cycle. This was associated with\nNF-?B and activator protein-1 activation and increased expression\nof the inhibitor of apoptosis, c-IAP1. However, oxidant stress-induced\napoptosiswas found to be caspase- and calpain-independent implicating\nCD40 ligation as a regulator of caspase-independent cell death.\nThis was confirmed by the demonstration that CD40 ligation prevented\nmitochondrial release and nuclear translocation of apoptosis\ninducing factor. In conclusion, we demonstrate a novel role for\nCD40 as a regulator of epithelial cell survival against oxidant stress.\nFurthermore, we have identified, for the first time, an endogenous\ninhibitory pathway of caspase-independent cell death."@en ; prodottidellaricerca:prodottoDi istituto:CDS014 , modulo:ID5465 , modulo:ID2669 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA8474 , unitaDiPersonaleInterno:MATRICOLA802 . ns11:ID510942 pubblicazioni:rivistaDi prodotto:ID12087 .