@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS013 prodottidellaricerca:prodotto prodotto:ID11319 . @prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA42199 pubblicazioni:autoreCNRDi prodotto:ID11319 . @prefix rdf: . prodotto:ID11319 rdf:type prodotto:TIPO1101 . @prefix retescientifica: . prodotto:ID11319 rdf:type retescientifica:ProdottoDellaRicerca . @prefix rdfs: . prodotto:ID11319 rdfs:label "Rb binding protein Che-1 interacts with Tau cerebellar granule neurons. Modulation during neuronal apoptosis. (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID11319 pubblicazioni:anno "2002-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID11319 skos:altLabel "
Barbato C, Corbi N, Canu N, Fanciulli M, Serafino A, Ciotti M, Libri V, Bruno T, Amadoro G, De Angelis R, Calissano P, Passananti C. (2002)
Rb binding protein Che-1 interacts with Tau cerebellar granule neurons. Modulation during neuronal apoptosis.
in Molecular and cellular neurosciences (Print)
"^^rdf:HTML ; pubblicazioni:autori "Barbato C, Corbi N, Canu N, Fanciulli M, Serafino A, Ciotti M, Libri V, Bruno T, Amadoro G, De Angelis R, Calissano P, Passananti C."^^xsd:string ; pubblicazioni:paginaInizio "1038"^^xsd:string ; pubblicazioni:paginaFine "1050"^^xsd:string ; pubblicazioni:numeroVolume "24"^^xsd:string . @prefix ns10: . prodotto:ID11319 pubblicazioni:rivista ns10:ID278870 ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:titolo "Rb binding protein Che-1 interacts with Tau cerebellar granule neurons. Modulation during neuronal apoptosis."^^xsd:string ; prodottidellaricerca:abstract "Che-1 is a recently identified human Rb binding protein that inhibits the Rb growth-suppressing function and regulates cell proliferation. Che-1 contacts the Rb and competes with HDAC1 for Rb-binding site, removing HDAC1 from the Rb/E2F cell cycle-regulated promoters. We have investigated the expression of Che-1 in neuronal cells and we showed that Che-1 directly interacts with Tau. Tau is a microtubule-associated protein involved in the assembly and stabilization of neuronal microtubules network that plays a crucial role modulating neuronal morphogenesis, axonal\nshape, and transport. In rat cerebellar granule neurons (CGNs) Che-1 partially colocalizes with Tau in the cytoplasm. Che-1 binds the amino-terminal region of Tau protein, which is not involved in microtubule interactions. Tau and Che-1 endogenous proteins coimmunoprecipitate from CGNs cellular lysates. In addition, Che-1/Tau interaction was demonstrated both in overexpressing COS-7 cells and CGNs by FRET analysis. Finally, we observed that Tau/Che-1 interaction is modulated during neuronal apoptosis." ; prodottidellaricerca:prodottoDi istituto:CDS013 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA42199 . ns10:ID278870 pubblicazioni:rivistaDi prodotto:ID11319 .