@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS013 prodottidellaricerca:prodotto prodotto:ID11296 . @prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA19796 pubblicazioni:autoreCNRDi prodotto:ID11296 . @prefix rdf: . @prefix retescientifica: . prodotto:ID11296 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1101 . @prefix rdfs: . prodotto:ID11296 rdfs:label " New data on the world distribution of paraoxonase (PON1 Gln 192 - Arg) gene frequencies. (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID11296 pubblicazioni:anno "2003-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID11296 skos:altLabel "
Scacchi R., Corbo R.M., Rickards O., and De Stefano G.F (2003)
New data on the world distribution of paraoxonase (PON1 Gln 192 - Arg) gene frequencies.
in Human biology (Print)
"^^rdf:HTML ; pubblicazioni:autori "Scacchi R., Corbo R.M., Rickards O., and De Stefano G.F"^^xsd:string ; pubblicazioni:paginaInizio "365"^^xsd:string ; pubblicazioni:paginaFine "373"^^xsd:string ; pubblicazioni:numeroVolume "75"^^xsd:string . @prefix ns10: . prodotto:ID11296 pubblicazioni:rivista ns10:ID383465 ; pubblicazioni:note "R.M. Corbo \u00E8 a disposizione dell'IBPM"^^xsd:string ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:titolo " New data on the world distribution of paraoxonase (PON1 Gln 192 - Arg) gene frequencies."^^xsd:string ; prodottidellaricerca:abstract "Human paraoxonase (PON), a serum enzyme that hydrolyses organophosphate insecticides and nerve agents, plays an unclear physiological role. Of the three genes in the paraoxonase gene family, PON1 shows a polymorphism, Gln 192- Arg, governed by two common alleles, named *Q and *R. These determine two different isoforms associated respectively with lower and higher activity towards paraoxon, a toxic metabolic product of the insecticide parathion. The *R allele has been often found associated with increased risk of coronary heart disease. As human populations go towards greater exposure to environmental changes, including changes in dietary habits, contact with insecticides or other toxic substances, health risks will change as well. In the prevention of these newly emerging risks, it could be important to know the distribution of the two alleles in the various world populations. In this paper we report on the genotype and allele frequencies in different populations, most of whom have never been examined for this polymorphism. Samples were taken from mainland Italy, Sardinia, Ethiopia, Benin, and Ecuador. The *R allele frequencies for the samples were: 0.313, 0.248, 0.408, 0.612, and 0.789, respectively. The data show a large variability in the allele frequencies, and in particular that the PON1 allele distribution depends on membership to different geographic populations." ; prodottidellaricerca:prodottoDi istituto:CDS013 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA19796 . ns10:ID383465 pubblicazioni:rivistaDi prodotto:ID11296 .