@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS040 prodottidellaricerca:prodotto prodotto:ID110581 . @prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA751 pubblicazioni:autoreCNRDi prodotto:ID110581 . unitaDiPersonaleInterno:MATRICOLA10324 pubblicazioni:autoreCNRDi prodotto:ID110581 . @prefix unitaDiPersonaleEsterno: . unitaDiPersonaleEsterno:ID8262 pubblicazioni:autoreCNRDi prodotto:ID110581 . @prefix modulo: . modulo:ID5927 prodottidellaricerca:prodotto prodotto:ID110581 . unitaDiPersonaleInterno:MATRICOLA10701 pubblicazioni:autoreCNRDi prodotto:ID110581 . @prefix rdf: . prodotto:ID110581 rdf:type prodotto:TIPO1302 . @prefix retescientifica: . prodotto:ID110581 rdf:type retescientifica:ProdottoDellaRicerca . @prefix rdfs: . prodotto:ID110581 rdfs:label "Non-farnesylated prelamin A mislocalization and disorganization of heterochromatin marker trimethyl-K9-histone 3 in Emery-Dreifuss Muscular Dystrophy fibroblasts after prelamin A interfering drug treatment. (Abstract/Poster in atti di convegno)"@en . @prefix xsd: . prodotto:ID110581 pubblicazioni:anno "2008-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID110581 skos:altLabel "
Capanni C, Columbaro M, Squarzoni S, Camozza D, Schena E, Wehnert M, Maraldi NM, Lattanzi G. (2008)
Non-farnesylated prelamin A mislocalization and disorganization of heterochromatin marker trimethyl-K9-histone 3 in Emery-Dreifuss Muscular Dystrophy fibroblasts after prelamin A interfering drug treatment.
in ASCB meeting 2008, San Francisco CA
"^^rdf:HTML ; pubblicazioni:autori "Capanni C, Columbaro M, Squarzoni S, Camozza D, Schena E, Wehnert M, Maraldi NM, Lattanzi G."^^xsd:string ; pubblicazioni:descrizioneSinteticaDelProdotto "Emery\u0096Dreifuss muscular dystrophy (EDMD) is a heterogeneous late-onset disease involving skeletal muscle wasting and heart defects caused by mutations of the inner nuclear membrane emerin (EDMD1), the nuclear lamina components lamin A/C (EDMD2) or the inner nuclear membrane binding proteins nesprin 1 (coding by SYNE1 gene ) and nesprine 2 (coding by SYNE2 gene). Since It has previously reported that in EDMD1 and in EDMD2 non-farnesylated prelamin A was mislocalized, we investigated the distribution of this protein precursor in EDMD fibroblasts harboring SYNE \u00961 and/or SYNE \u00962 genes mutations. In order to induce the accumulation of non-farnesylated lamin A precursor we treated EDMD fibroblasts with mevinolin, an inhibitor of 3-hydroxy-3-methylglutaryl-CoA reductase, that interferes with prelamin A farnesylation. The immunofluorescence detection of prelamin A and the electron microscopy analysis of treated cells clearly showed that the number and the distribution pattern of non-farnesylated prelamin A aggregates were altered. Moreover, the accumulation of non-farnesylated lamin A precursor either in EDMD fibroblasts harboring LMNA gene mutations or in EDMD fibroblasts harboring SYNE 1 and 2 genes mutations was not able to induce the redistribution of heterochromatin marker trimethyl-K9-histone 3 at the prelamin A aggregates level as showed in control cells. \nThese results suggest that non-farnesylated prelamin A localization and its effect on heterochromatin remodeling could be related to the nesprin/emerin/lamin interactions."^^xsd:string ; pubblicazioni:affiliazioni "IGM-CNR Unit of Bologna"^^xsd:string ; pubblicazioni:titolo "Non-farnesylated prelamin A mislocalization and disorganization of heterochromatin marker trimethyl-K9-histone 3 in Emery-Dreifuss Muscular Dystrophy fibroblasts after prelamin A interfering drug treatment."^^xsd:string ; prodottidellaricerca:prodottoDi modulo:ID5927 , istituto:CDS040 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA10324 , unitaDiPersonaleInterno:MATRICOLA751 , unitaDiPersonaleEsterno:ID8262 , unitaDiPersonaleInterno:MATRICOLA10701 . @prefix parolechiave: . prodotto:ID110581 parolechiave:insiemeDiParoleChiave . parolechiave:insiemeDiParoleChiaveDi prodotto:ID110581 .