@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS035 prodottidellaricerca:prodotto prodotto:ID109322 . @prefix modulo: . modulo:ID7890 prodottidellaricerca:prodotto prodotto:ID109322 . @prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA9489 pubblicazioni:autoreCNRDi prodotto:ID109322 . unitaDiPersonaleInterno:MATRICOLA11035 pubblicazioni:autoreCNRDi prodotto:ID109322 . @prefix rdf: . @prefix retescientifica: . prodotto:ID109322 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1304 . @prefix rdfs: . prodotto:ID109322 rdfs:label "Optimal use of silica nanoparticles for enhanced ultrasound imaging and automatic tissue typing (Abstract/Poster in convegno)"@en . @prefix xsd: . prodotto:ID109322 pubblicazioni:anno "2010-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID109322 skos:altLabel "
Conversano F., Ragusa A., Greco A., Casciaro S. (2010)
Optimal use of silica nanoparticles for enhanced ultrasound imaging and automatic tissue typing
in The 15th European Symposium on Ultrasound Contrast Imaging, Rotterdam , The Netherlands, 21-22 Gennaio 2010
"^^rdf:HTML ; pubblicazioni:autori "Conversano F., Ragusa A., Greco A., Casciaro S."^^xsd:string ; pubblicazioni:note "Abstract, pp. 70 - 73. F. ten Cate, N. de Jong, T. Albrecht (eds.). Erasmus MC Rotterdam, The Netherlands, 2010."^^xsd:string ; pubblicazioni:descrizioneSinteticaDelProdotto "Nowadays, all contrast agents that are approved for clinical ultrasound imaging applications consist of encapsulated gas microbubbles of a few micrometers, able to produce strong signal backscatter when insonified at frequencies belonging to the \\\"diagnostic\\\" range (typically 1-10 MHz). Since microbubbles cannot leave the vascular space, they cannot reach cells located beyond the capillary vasculature, such as many cancer cells. Actually, tumour angiogenesis vessels have the tendency to be \\\"leaky\\\" and to exhibit the so-called EPR (enhanced permeability and retention) effect, which results in exaggerated extravasation and retention of particles that are smaller than the pore size of tumour endothelium (typically between 380 and 780 nm). For these reasons, intensive investigations have been undertaken to develop nano-sized cancer targeting agents for ultrasound molecular imaging. The most significant experiments involving nanoparticles (NPs) as ultrasound contrast agents were carried out on nanobubbles, perfluorocarbon nanodroplets and echogenic liposomes. The use of solid NPs provides higher signal enhancement as well as longer stability than liquid and gaseous particles of the same size. Nevertheless, ultrasound investigations of solid NPs have been until now limited to very high frequencies (30-40 MHz), whose clinical usefulness is restricted to few highly specific applications. In this work we demonstrated the feasibility of using silica NPs as ultrasound contrast agents at common diagnostic frequencies, by investigating the enhancement produced by varying particle concentration and diameter in a range of clinical interest for tumour targeting and subsequent automatic detection through radiofrequency (RF) signal analysis."^^xsd:string ; skos:note "Poster"^^xsd:string ; pubblicazioni:affiliazioni "National Research Council, Institute of Clinical Physiology, Lecce, Italy"^^xsd:string ; pubblicazioni:titolo "Optimal use of silica nanoparticles for enhanced ultrasound imaging and automatic tissue typing"^^xsd:string ; prodottidellaricerca:prodottoDi modulo:ID7890 , istituto:CDS035 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA9489 , unitaDiPersonaleInterno:MATRICOLA11035 . @prefix parolechiave: . prodotto:ID109322 parolechiave:insiemeDiParoleChiave . parolechiave:insiemeDiParoleChiaveDi prodotto:ID109322 .