@prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . @prefix prodotto: . unitaDiPersonaleInterno:MATRICOLA42109 pubblicazioni:autoreCNRDi prodotto:ID109075 . @prefix prodottidellaricerca: . @prefix istituto: . istituto:CDS035 prodottidellaricerca:prodotto prodotto:ID109075 . @prefix modulo: . modulo:ID6306 prodottidellaricerca:prodotto prodotto:ID109075 . @prefix rdf: . @prefix retescientifica: . prodotto:ID109075 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1105 . @prefix rdfs: . prodotto:ID109075 rdfs:label "Extended donor criteria in heart transplantation with pharmacological stress echocardiography (Abstract in rivista)"@en . @prefix xsd: . prodotto:ID109075 pubblicazioni:anno "2007-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID109075 skos:altLabel "
Bombardini T.; Arpesella G.; Gherardi S.; Maccherini M.; Serra W.; Giancarlo T.; Tanganelli P.; Picano E. (2007)
Extended donor criteria in heart transplantation with pharmacological stress echocardiography
in European Heart Journal, 2007
"^^rdf:HTML ; pubblicazioni:autori "Bombardini T.; Arpesella G.; Gherardi S.; Maccherini M.; Serra W.; Giancarlo T.; Tanganelli P.; Picano E."^^xsd:string ; pubblicazioni:convegno "European Heart Journal"^^xsd:string ; pubblicazioni:note "In: European Heart Journal, vol. 28 pp. 548 -. Oxford Journals, 2007."^^xsd:string ; pubblicazioni:descrizioneSinteticaDelProdotto "Background: Because of the shortage of donor heart, the criteria for acceptance have been considerably extended. Pharmacological stress echocardiography is highly accurate for excluding prognostically significant coronary artery disease. Aim: to establish the feasibility of an approach based on pharmacological stress echo as a gatekeeper for extended heart donor criteria. Methods: Starting April 2005 to January 2007, 9 \\\"marginal\\\" candidate donors (56\u00B19 years, 5 men) were initially enrolled. After legal declaration of brain death, all marginal donors underwent bedside echocardiography, with baseline and (when resting echo was normal) dipyridamole (0.84 mg/kg in 6') or dobutamine (up to 40 mcg/kg) stress echocardiography. Eligible hearts (with normal echo findings) were transplanted and underwent coronary angiography at 1 month after transplant; non-eligible hearts (with abnormal echo findings) were excluded and subjected to cardio-autoptic verification. Results: interpretable echocardiograms were obtained in all 9 patients. Resting echo showed obvious resting wall motion abnormalities in 2 patients (excluded from donation). Stress echo was successfully performed in the remaining 7 (with dipyridamole in 6, and dobutamine in 1) and results were abnormal in 2, in whom coronary artery disease was confirmed by autoptic verification (see figure). The remaining 5 hearts were uneventfully transplanted in marginal recipients. All recipients showed normal findings and coronary angiography and intravascular ultrasound at 1-month post-transplant and are alive at 1-21 months follow-up. Conclusion: Bedside pharmacological stress echocardiography can safely be performed in candidate heart donors with brain death, and shows potential to extend donor criteria in heart transplantation."^^xsd:string ; pubblicazioni:titolo "Extended donor criteria in heart transplantation with pharmacological stress echocardiography"^^xsd:string ; prodottidellaricerca:prodottoDi istituto:CDS035 , modulo:ID6306 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA42109 . @prefix parolechiave: . prodotto:ID109075 parolechiave:insiemeDiParoleChiave . parolechiave:insiemeDiParoleChiaveDi prodotto:ID109075 .