@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS009 prodottidellaricerca:prodotto prodotto:ID10443 . @prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA4544 pubblicazioni:autoreCNRDi prodotto:ID10443 . @prefix modulo: . modulo:ID2644 prodottidellaricerca:prodotto prodotto:ID10443 . @prefix rdf: . prodotto:ID10443 rdf:type prodotto:TIPO1101 . @prefix retescientifica: . prodotto:ID10443 rdf:type retescientifica:ProdottoDellaRicerca . @prefix rdfs: . prodotto:ID10443 rdfs:label "SPECT predictors of cognitive decline and Alzheimer's disease in mild cognitive impairment (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID10443 pubblicazioni:anno "2009-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID10443 skos:altLabel "
Nobili F. 1, De Carli F. 2, Frisoni G.B. 3, Portet F. 4, Verhey F. 5, Rodriguez G. 1, Caroli A. 3,6, Touchon J. 4, Morbelli S. 7, Guerra U.P. 8, Dessi B. 1, Brugnolo A. 1, Visser P.J. 5,9 (2009)
SPECT predictors of cognitive decline and Alzheimer's disease in mild cognitive impairment
in Journal of Alzheimer's disease
"^^rdf:HTML ; pubblicazioni:autori "Nobili F. 1, De Carli F. 2, Frisoni G.B. 3, Portet F. 4, Verhey F. 5, Rodriguez G. 1, Caroli A. 3,6, Touchon J. 4, Morbelli S. 7, Guerra U.P. 8, Dessi B. 1, Brugnolo A. 1, Visser P.J. 5,9"^^xsd:string ; pubblicazioni:paginaInizio "761"^^xsd:string ; pubblicazioni:paginaFine "772"^^xsd:string ; pubblicazioni:numeroVolume "17"^^xsd:string . @prefix ns11: . prodotto:ID10443 pubblicazioni:rivista ns11:ID176013 ; pubblicazioni:note "Pubblicato on-line: 19 Giugno 2009.\nCorresponding author: F. Nobili (flaviomariano.nobili@hsanmartino.it)\nIF 2009: 3.832"^^xsd:string ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "1. Clinical Neurophysiology Unit, Dept of Endocrinological and Medical Sciences, University of Genoa, Genoa.\n2. Institute of Molecular Bioimaging and Physiology, National Research Council, Genoa.\n3. LENITEM - Laboratory of Epidemiology Neuroimaging & Telemedicine, IRCCS San Giovanni di Dio Fatebenefratelli, Brescia\n4. Centre Memoire de Ressource et de Recherche, Service de Neurologie, CHU Guy de Chauliac, Montpellier (France).\n5. Department of Psychiatry and Neuropsychology, University of Maastricht (Olanda)\n6. Medical Imaging Unit, Biomedical Engineering Department, Mario Negri Institute, Bergamo.\n7. Nuclear Medicine Unit, Department of Internal Medicine, University of Genoa, Genoa.\n8. Nuclear Medicine Unit, Ospedali Riuniti of Bergamo, Bergamo.\n9. Department of Neurology, VU University Medical Centre, Amsterdam (Olanda)"^^xsd:string ; pubblicazioni:titolo "SPECT predictors of cognitive decline and Alzheimer's disease in mild cognitive impairment"^^xsd:string ; prodottidellaricerca:abstract "Baseline brain single photon emission computed tomography (SPECT) was evaluated in eighty subjects with mild cognitive impairment (MCI) who were followed for a mean of about two years, when twelve patients developed Alzheimer's disease (AD), nineteen showed memory decline (D), and forty-three had normal cognition assessment (stable: S) (six drop-out). Volumetric Regions of Interest (VROI) analysis was performed in six associative cortical areas in each hemisphere. ANOVA for repeated measures showed significant effects for both the group (S, D, and AD; p < 0.004) and VROI (p < 0.0001) factors, with significant group*region interaction (p < 0.01). At post-hoc comparison, hippocampal VROIs values were lower in AD than in D and S, while parietal VROIs values were lower in D and AD than in S. These four VROI significantly correlated with verbal delayed recall score at follow-up visit. Receiver operating characteristic (ROC) curves for the mean hippocampal VROI value showed 0.81 sensitivity with 0.86 specificity in separation of S+D from AD (p < 0.0001), and 0.69 sensitivity with 0.75 specificity in separation of S from D+AD (p < 0.0002). ROC curves for the mean parietal VROI value showed 0.62 sensitivity with 0.70 specificity in separation of S from D+AD (p < 0.0002). Baseline SPECT can support outcome prediction in subjects with MCI." ; prodottidellaricerca:prodottoDi istituto:CDS009 , modulo:ID2644 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA4544 . @prefix parolechiave: . prodotto:ID10443 parolechiave:insiemeDiParoleChiave . ns11:ID176013 pubblicazioni:rivistaDi prodotto:ID10443 . parolechiave:insiemeDiParoleChiaveDi prodotto:ID10443 .