@prefix pubblicazioni: . @prefix unitaDiPersonaleEsterno: . @prefix prodotto: . unitaDiPersonaleEsterno:ID28 pubblicazioni:autoreCNRDi prodotto:ID10335 . @prefix prodottidellaricerca: . @prefix istituto: . istituto:CDS009 prodottidellaricerca:prodotto prodotto:ID10335 . unitaDiPersonaleEsterno:ID6007 pubblicazioni:autoreCNRDi prodotto:ID10335 . @prefix modulo: . modulo:ID2660 prodottidellaricerca:prodotto prodotto:ID10335 . unitaDiPersonaleEsterno:ID29 pubblicazioni:autoreCNRDi prodotto:ID10335 . @prefix rdf: . prodotto:ID10335 rdf:type prodotto:TIPO1101 . @prefix retescientifica: . prodotto:ID10335 rdf:type retescientifica:ProdottoDellaRicerca . @prefix rdfs: . prodotto:ID10335 rdfs:label "Detection of Lymph-Node Metastases with Integrated [(11)C]Choline PET/CT in Patients with PSA Failure after Radical Retropubic Prostatectomy: Results Confirmed by Open Pelvic-Retroperitoneal Lymphadenectomy (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID10335 pubblicazioni:anno "2007-01-01T00:00:00+01:00"^^xsd:gYear ; pubblicazioni:doi "10.1016/j.eururo.2007.03.03"^^xsd:string . @prefix skos: . prodotto:ID10335 skos:altLabel "
Scattoni V.1, Picchio M. 2, Suardi N. 1, Messa C. 2, Freschi M. 3, Roscigno M. 1, Da Pozzo L. 1, Bocciardi A. 1, Rigatti P. 1, Fazio F. 2 (2007)
Detection of Lymph-Node Metastases with Integrated [(11)C]Choline PET/CT in Patients with PSA Failure after Radical Retropubic Prostatectomy: Results Confirmed by Open Pelvic-Retroperitoneal Lymphadenectomy
in European urology
"^^rdf:HTML ; pubblicazioni:autori "Scattoni V.1, Picchio M. 2, Suardi N. 1, Messa C. 2, Freschi M. 3, Roscigno M. 1, Da Pozzo L. 1, Bocciardi A. 1, Rigatti P. 1, Fazio F. 2"^^xsd:string ; pubblicazioni:paginaInizio "423"^^xsd:string ; pubblicazioni:paginaFine "429"^^xsd:string ; pubblicazioni:numeroVolume "52"^^xsd:string . @prefix ns11: . prodotto:ID10335 pubblicazioni:rivista ns11:ID336785 ; pubblicazioni:pagineTotali "7"^^xsd:string ; pubblicazioni:numeroFascicolo "2"^^xsd:string ; skos:note "PubMe"^^xsd:string , "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "1. Department of Urology, University Vita-Salute, Scientific Institute San Raffaele, Milan, Italy\n2. Department of Nuclear Medicine, Scientific Institute San Raffaele, IBFM-CNR, University Milano-Bicocca, Milan, Italy\n3. Department of Pathology, University Vita-Salute, Scientific Institute San Raffaele, Milan, Italy"^^xsd:string ; pubblicazioni:titolo "Detection of Lymph-Node Metastases with Integrated [(11)C]Choline PET/CT in Patients with PSA Failure after Radical Retropubic Prostatectomy: Results Confirmed by Open Pelvic-Retroperitoneal Lymphadenectomy"^^xsd:string ; prodottidellaricerca:abstract "OBJECTIVES: To prospectively evaluate the accuracy of integrated [(11)C]choline-PET/CT in the diagnosis of lymph-node recurrence in prostate cancer patients with biochemical failure after surgery. METHODS: Since October 2002, 25 patients with biochemical recurrence (median PSA: 1.98ng/ml), based on evidence of lymph-node metastases on [(11)C]choline-PET/CT scan (21 cases) or conventional imaging (4 cases), were scheduled for either bilateral pelvic (12 cases) or both pelvic and retroperitoneal lymph-node dissection (13 patients). RESULTS: Sixty-three nodal sites were evaluated histologically. The mean number of nodes removed and positive nodes were 21.92+/-16.91 (range: 4-74) and 8.84+/-9.65 (range: 1-31), respectively. Of the four patients with negative [(11)C]choline-PET/CT and positive magnetic resonance, none had nodal metastases. Nineteen of the 21 patients (90%) with positive [(11)C]choline-PET/CT had nodal metastases of prostate adenocarcinoma at histologic evaluation. A lesion-based analysis showed that [(11)C]choline-PET/CT sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 64%, 90%, 86%, 72%, and 77%, respectively. The mean maximum diameter of true positive metastases was larger than false-negative ones (15.0 vs. 6.3mm; p=0.0004). CONCLUSIONS: [(11)C]Choline-PET/CT is an accurate diagnostic tool for the detection of lymph-node metastases of recurrent prostate cancer. The low negative predictive value seems to depend on the limited capability of [(11)C]choline-PET/CT to detect microscopic lesions. The high positive predictive value, even with low PSA values, provides a basis for further treatment decisions."@en ; prodottidellaricerca:prodottoDi istituto:CDS009 , modulo:ID2660 ; pubblicazioni:autoreCNR unitaDiPersonaleEsterno:ID6007 , unitaDiPersonaleEsterno:ID29 , unitaDiPersonaleEsterno:ID28 . @prefix parolechiave: . prodotto:ID10335 parolechiave:insiemeDiParoleChiave . ns11:ID336785 pubblicazioni:rivistaDi prodotto:ID10335 . parolechiave:insiemeDiParoleChiaveDi prodotto:ID10335 .