@prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . @prefix prodotto: . unitaDiPersonaleInterno:MATRICOLA7591 pubblicazioni:autoreCNRDi prodotto:ID103347 . unitaDiPersonaleInterno:MATRICOLA8922 pubblicazioni:autoreCNRDi prodotto:ID103347 . unitaDiPersonaleInterno:MATRICOLA5792 pubblicazioni:autoreCNRDi prodotto:ID103347 . unitaDiPersonaleInterno:MATRICOLA921 pubblicazioni:autoreCNRDi prodotto:ID103347 . @prefix prodottidellaricerca: . @prefix istituto: . istituto:CDS014 prodottidellaricerca:prodotto prodotto:ID103347 . unitaDiPersonaleInterno:MATRICOLA8495 pubblicazioni:autoreCNRDi prodotto:ID103347 . unitaDiPersonaleInterno:MATRICOLA8987 pubblicazioni:autoreCNRDi prodotto:ID103347 . unitaDiPersonaleInterno:MATRICOLA11467 pubblicazioni:autoreCNRDi prodotto:ID103347 . @prefix modulo: . modulo:ID7511 prodottidellaricerca:prodotto prodotto:ID103347 . @prefix rdf: . prodotto:ID103347 rdf:type prodotto:TIPO1302 . @prefix retescientifica: . prodotto:ID103347 rdf:type retescientifica:ProdottoDellaRicerca . @prefix rdfs: . prodotto:ID103347 rdfs:label "Estrogen and androgen regulation of the small heat shock protein \u00B1A-crystallin: New perspectives on sex steroid implication in age-related disorders associated with proteotoxic stress. (Abstract/Poster in atti di convegno)"@en . @prefix xsd: . prodotto:ID103347 pubblicazioni:anno "2010-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID103347 skos:altLabel "
C. D'Anna; C. Cascio; D. Cigna; G. Galizzi; I. Deidda; I. Bianchi; D. Russo; G. Drago; R. Passantino; L. Bini; P. Guarneri. (2010)
Estrogen and androgen regulation of the small heat shock protein \u00B1A-crystallin: New perspectives on sex steroid implication in age-related disorders associated with proteotoxic stress.
in 7th European Congress of Biogerontology, October 14th- 17th, Palermo, October 16th
"^^rdf:HTML ; pubblicazioni:autori "C. D'Anna; C. Cascio; D. Cigna; G. Galizzi; I. Deidda; I. Bianchi; D. Russo; G. Drago; R. Passantino; L. Bini; P. Guarneri."^^xsd:string ; skos:note "Abstract"^^xsd:string ; pubblicazioni:affiliazioni "IBIM-CNR"^^xsd:string ; pubblicazioni:titolo "Estrogen and androgen regulation of the small heat shock protein \u00B1A-crystallin: New perspectives on sex steroid implication in age-related disorders associated with proteotoxic stress."^^xsd:string ; prodottidellaricerca:abstract "Sex steroids, here especially referring to estrogens and androgens, have an important impact on the anatomy,\nphysiology and pathophysiology of the eye and brain. Gender dissimilarities are reported in the structural\nand functional organization of ocular and brain tissues and there is compelling evidence that fluctuations in\nthe levels of sex steroids during life affect neural functions. Studies especially highlight their critical role in\nthe pathogenesis of age-related ocular diseases just as neurodegenerative diseases, which share the common\npathological mechanism of protein aggregation. For instance, estrogen depletion in postmenopausal women\nis associated with higher risk of developing age-related macular degeneration (AMD) as well as Alzheimer's\ndisease, and risks seem to be relieved among postmenopausal hormone users (1-2). An estrogen receptor\nrepressor induces cataract formation in transgenic mice and androgen effects are associated with dry eye\nsyndromes.\nHuman and mammalian ocular and brain tissues possess estrogen receptor subtypes androgen receptors and\nenzymes of synthesis and metabolism of their ligands. Our own investigations set the adult retina as an\nandrogenic and estrogenic tissue where synthesis and function of testosterone and its transformed product\nestradiol may rely on the control of aromatase and presence of ER?, ER? and ARs (3), and they are both\ninvolved in survival mechanisms during in vitro retinal ischemia (4).\nHowever, the functional pathways of sex steroids are only partly understood and the broad range of their\neffects makes it plausible that many target molecules are still unknown. Using the intravitreal injection\ntechnique, which is a mainstay of ophthalmic practice, 2-DE gels and MALDI-TOF-MS analyses we\nexplored the effects of treatments with the bioactive 17?-estradiol or androgen dihydrotestosterone (DHT) on\nthe retinal proteome. We identified three sex steroid-regulated proteins: the galectin-related-inter-fiber\n(GRIFIN) which is a galectin family member protein of unknown function, the fatty acid-binding epidermal-\n5 (FABP5) protein responsible for the fatty acid uptake and transport, and the small heat shock ?A-crystallin\n(CRYAA) protein involved in preventing aggregation of denatured or unfolded proteins. This study first\ndemonstrates the regulation of these proteins after intravitreal injection of sex steroids. It is noteworthy that\nCRYAA, estrogens and androgens have antioxidant and antiapoptotic properties and reduce amyloid ?-\npeptide accumulation and toxicity (5); moreover, age-related ocular and neurodegenerative protein\nmisfolding diseases are associated with crystallins changes and sex steroid depletion. Although some clinical\nstudies disclose benefits among hormone therapy users, the therapeutic value of estrogens and androgens is\nfar to be definitive and studies are needed. Our findings on sex steroid-mediated regulation of ?A-crystallin,\nGRIFIN and FABP5 give evidence for novel mechanism(s) of sex steroids and a potential link to age-related\ndisorders associated with proteotoxic stress."@en ; prodottidellaricerca:prodottoDi istituto:CDS014 , modulo:ID7511 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA8495 , unitaDiPersonaleInterno:MATRICOLA11467 , unitaDiPersonaleInterno:MATRICOLA8922 , unitaDiPersonaleInterno:MATRICOLA8987 , unitaDiPersonaleInterno:MATRICOLA5792 , unitaDiPersonaleInterno:MATRICOLA921 , unitaDiPersonaleInterno:MATRICOLA7591 .