@prefix commesse: . @prefix commessa: . @prefix modulo: . commessa:ID5660 commesse:modulo modulo:ID8561 . @prefix istituto: . istituto:CDS039 commesse:istitutoEsecutoreDi modulo:ID8561 . @prefix descrizioni: . @prefix commessa-statoavanzamento: . commessa-statoavanzamento:MODULO-ID8561 descrizioni:descrizioneDi modulo:ID8561 . @prefix moduli: . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA22107 moduli:gestoreDi modulo:ID8561 . @prefix rdf: . @prefix retescientifica: . modulo:ID8561 rdf:type retescientifica:Modulo . @prefix rdfs: . modulo:ID8561 rdfs:label "Progetto AIRC: MiRNAs in tumorigenesis: novel oncosuppressor targets and miRNA-mediated control of AP-1 transcription factors (SV.P15.007.002)"@it . @prefix xsd: . @prefix strutture: . modulo:ID8561 strutture:codice "SV.P15.007.002"^^xsd:string ; commesse:annoDiChiusuraPrevisto "2013-01-01T00:00:00+01:00"^^xsd:gYear ; commesse:istitutoEsecutore istituto:CDS039 ; commesse:abstract "Several tumor-associated miRNAs have been characterized as components of regulatory feedback loops involving oncogenic and oncosuppressor transcription factors, such as Myc, NF-kB and p53. MiRNAs, in turn, can control the synthesis of their own transactivators, by both direct and indirect mechanisms forming complex regulatory networks.\nThe AP-1 transcription factors are key targets of multiple tumorigenic pathways. The oncogenic role of AP-1 is complex, because of the large number of homo- and hetero- dimers formed by JUN and FOS family members, which play distinct, sometimes antagonistic functions, depending on the cell-context.\nRecently, in an in vitro system of thyroid cell transformation, we have reported that the miR-21 precursor (pri-miR-21) is transcriptionally regulated by AP-1 in response to the RAS oncoprotein.\nIn this project, we will:\n- identify novel tumor suppressor targets of miR-21 in multiple tumor cell lines;\n- characterize the mechanisms of miRNA-mediated regulation of various AP-1 components in neoplastic transformation;\n- adopt high-throughput approaches, based on AP-1-regulated reporters as readouts for functional screening of miRNAs affecting AP-1 activity."@it ; retescientifica:nome "Progetto AIRC: MiRNAs in tumorigenesis: novel oncosuppressor targets and miRNA-mediated control of AP-1 transcription factors"@it ; descrizioni:descrizione commessa-statoavanzamento:MODULO-ID8561 . @prefix modulo-descrizione: . modulo:ID8561 descrizioni:descrizione modulo-descrizione:ID8561 . @prefix commessa-collaborazioni: . modulo:ID8561 descrizioni:descrizione commessa-collaborazioni:MODULO-ID8561 ; commesse:moduloDi commessa:ID5660 ; moduli:gestore unitaDiPersonaleInterno:MATRICOLA22107 . modulo-descrizione:ID8561 descrizioni:descrizioneDi modulo:ID8561 . commessa-collaborazioni:MODULO-ID8561 descrizioni:descrizioneDi modulo:ID8561 .