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Istituto di tecnologie biomediche

Torna all'elenco Contributi in rivista anno 2015

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Ochratoxin A as possible factor trigging autism and its male prevalence via epigenetic mechanism.

Anno di pubblicazione: 2015

Formato: Elettronico Cartaceo

Autori: Mezzelani A, Raggi ME, Marabotti A, Milanesi L.

Affiliazioni autori: 1: Institute of Biomedical Technologies, National Research Council, Via Fratelli Cervi 93, 20090 Segrate, MI, Italy 2: Scientific Institute, IRCCS Eugenio Medea, Bosisio Parini, Lecco, Italy 3: Department of Chemistry and Biology, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, SA, Italy

Autori CNR:

  • ANNA MARABOTTI
  • ALESSANDRA MARIA MEZZELANI
  • LUCIANO MILANESI

Lingua: inglese

Abstract: The role of dysbiosis causing leaky gut with xenobiotic production and absorption is increasingly demonstrated in autism spectrum disorder (ASD) pathogenesis. Among xenobiotics, we focused on ochratoxin A (one of the major food contaminating mycotoxin), that in vitro and in vivo exerts a male-specific neurotoxicity probably via microRNA modulation of a specific target gene. Among possible targets, we focused on neuroligin4X. Interestingly, this gene carries some SNPs already correlated with the disease and with illegitimate microRNA binding sites and, being located on X-chromosome, could explain the male prevalence. In conclusion, we propose a possible gene-environment interaction triggering ASD explaining the epigenetic neurotoxic mechanism activated by ochratoxin A in genetically predisposed children. This mechanism offers a clue for male prevalence of the disease and may have an important impact on prevention and cure of ASD.

Lingua abstract: inglese

Pagine da: 1

Pagine a: 4

Pagine totali: 4

Rivista:

Nutritional neuroscience Taylor & Francis Health Sciences
Paese di pubblicazione: Regno Unito
Lingua: inglese
ISSN: 1476-8305

Numero volume: 2015 Jan 17.

DOI: 10.1179/1476830515Z.000000000186

Referee: Sė: Internazionale

Indicizzato da: PubMed [PMID: 25597866]

Parole chiave:

  • Autism
  • Male-prevalence
  • Environment
  • Microbiota
  • Epigenetics
  • Ochratoxin A

Strutture CNR:

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