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Istituto di scienze e tecnologie della cognizione

Torna all'elenco Contributi in rivista anno 2011

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Self-rating scales assessing subjective well-being and distress correlate with rCBF in PTSD-sensitive regions

Anno di pubblicazione: 2011

Formato: Cartaceo

Autori: Nardo D, Högberg G, Flumeri F, Jacobsson H, Larsson SA, Hällström T, Pagani M

Affiliazioni autori: Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy Department of Clinical Neuroscience, Section for Psychiatry, Huddinge, Karolinska Institute, Stockholm, Sweden Department of Psychology, University of Rome La Sapienza, Rome, Italy Department of Nuclear Medicine, Karolinska Hospital, Stockholm, Sweden Institute of Cognitive Sciences and Technologies, CNR, Rome, Italy

Autori CNR:


Lingua: inglese

Abstract: Background: The aim of this study was to investigate the distribution of the regional cerebral blood flow (rCBF) in occupational-related PTSD subjects and to seek for possible correlations between brain perfusion and self-rating scales (SRSs) in order to cross-check their diagnostic value and to look for their neural correlates. Method: Thirteen traumatized underground and long-distance train drivers developing (S) and 17 not developing (NS) PTSD having experienced a “person under train” accident or having been assaulted at work underwent clinical assessment and 99mTc-HMPAO SPECT imaging during autobiographical trauma scripts. Statistical parametric mapping (SPM2) was applied to analyze rCBF changes in S as compared to NS, and to search for correlations between rCBF and the administered SRSs scores, modeling age, months to SPECT, and the ratio ‘gray matter/intra-cranial volume’ as nuisance variables. Results: Significantly higher activity was observed during trauma script in left posterior and anterior insula, posterior cingulate, inferior parietal lobule, precuneus, caudate and putamen in PTSD subjects as compared to trauma-exposed control group. Impact of Event Scale (IES) and World Health Organisation (ten) Well-Being Index (WHO-10) scores highly correlated with tracer uptake to a great extent in the same regions in which rCBF differences between S and NS were found. Conclusions: These findings support the involvement of insular, cingulate, and parietal cortices (as well as the basal ganglia) in the pathogenesis of PTSD and in the processing of related subjective well-being and distress.

Pagine da: 2549

Pagine a: 2561

Pagine totali: 12


Psychological medicine Cambridge University Press
Paese di pubblicazione: Regno Unito
Lingua: inglese
ISSN: 0033-2917

Numero volume: 41

Referee: Sì: Internazionale

Parole chiave:

  • PTSD
  • CBF
  • IES
  • WHO-10

Strutture CNR:


Allegati: 2011 PM PTSD SPECT IES WHO (application/pdf)

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