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Istituto di scienze e tecnologie della cognizione

Torna all'elenco Contributi in rivista anno 2011

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Alterations in cerebral blood flow as assessed by PET/CT in adults with Autism Spectrum Disorder with normal IQ

Anno di pubblicazione: 2011

Formato: Cartaceo

Autori: Pagani M, Manouilenko I, Stone-Elander S, Odh R, Salmaso D, Hatherly R, Brolin F, Jacobsson H, Larsson SA, Bejerot

Affiliazioni autori: M. Pagani  R. Odh  R. Hatherly  F. Brolin  H. Jacobsson  S. A. Larsson Department of Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden M. Pagani ( & )  D. Salmaso Institute of Cognitive Sciences and Technologies, CNR, Via Palestro 32, 00185 Rome, Padua, Italy e-mail: marco.pagani@istc.cnr.it I. Manouilenko  S. Stone-Elander  S. Bejerot Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden

Autori CNR:

  • MARCO PAGANI
  • DARIO SALMASO

Lingua: inglese

Abstract: Specific biological markers for Autism Spectrum Disorder (ASD) have not yet been established. Functional studies have shown abnormalities in the anatomo-functional connectivity of the limbic-striatal “social” brain. This study aimed to investigate regional cerebral blood flow (rCBF) at rest. Thirteen patients with ASD of normal intelligence and ten IQ-, sex- and age-matched healthy controls (HC) underwent PET/CT using [1-11C]butanol, a perfusion tracer. As compared to HC, ASD showed significant CBF increases in the right parahippocampal, posterior cingulate, primary visual and temporal cortex, putamen, caudatus, substantia nigra and cerebellum. No statistically significant correlation between CBF and IQ was found. The limbic, posterior associative and cerebellar cortices showed increased blood flow in ASD, confirming previous findings about the neurobiology of ASD.

Pagine da: 313

Pagine a: 318

Pagine totali: 6

Rivista:

Journal of autism and developmental disorders Plenum Press.
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 0162-3257

Numero volume: 42

Parole chiave:

  • Asperger
  • PET/CT
  • 11C-butanol
  • CBF

Strutture CNR:

Moduli:

Allegati: 2012 JADD PET ASD (application/pdf)

 
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