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Istituto di scienze e tecnologie della cognizione

Torna all'elenco Contributi in rivista anno 2011

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Copper in Alzheimer's Disease: A Meta-Analysis of Serum,Plasma, and Cerebrospinal Fluid Studies

Anno di pubblicazione: 2011

Formato: Cartaceo

Autori: Serena Bucossi1, Mariacarla Ventriglia1, 2, Valentina Panetta3, Carlo Salustri4, Patrizio Pasqualetti3, Stefania Mariani1, 2, Mariacristina Siotto1, Paolo Maria Rossini2, 5, Rosanna Squitti1, 2

Affiliazioni autori: 1Department of Neurology, "Campus Biomedico" University, Rome, Italy 2Department of Neuroscience, AFaR - Fatebenefratelli Hospital, Isola Tiberina, Rome, Italy 3Medical Statistics & Information Technology, AFaR - Fatebenefratelli Hospital, Isola Tiberina, Rome, Italy 4Institute of Cognition Sciences and Technologies (CNR), Fatebenefratelli Hospital, Isola Tiberina, Rome, Italy 5Department of Imaging, San Raffaele Cassino, Cassino (FR), Italy

Autori CNR:

  • CARLO SALUSTRI

Lingua: inglese

Abstract: There is an ongoing debate on the involvement of systemic copper (Cu) dysfunctions in Alzheimer's disease (AD), and clinical studies comparing Cu levels in serum, plasma, and cerebrospinal fluid (CSF) of AD patients with those of healthy controls have delivered non-univocal and often conflicting results. In an attempt to evaluate whether Cu should be considered a potential marker of AD, we applied meta-analysis to a selection of 26 studies published in the literature. Meta-analysis is a quantitative method that combines the results of independent reports to distinguish between small effects and no effects, random variations, variations in sample used, or in different analytical approaches. The subjects' sample obtained by merging studies was a pooled total of 761 AD subjects and 664 controls for serum Cu studies, 205 AD subjects and 167 controls for plasma Cu, and of 116 AD subjects and 129 controls for CSF Cu. Our meta-analysis of serum data showed that AD patients have higher levels of serum Cu than healthy controls. Plasma data did not allow conclusions, due to their high heterogeneity, but the meta-analysis of the combined serum and plasma studies confirmed higher Cu levels in AD. The analysis of CSF data, instead, revealed no difference between AD patients and controls.

Lingua abstract: inglese

Pagine da: 175

Pagine a: 185

Pagine totali: 11

Rivista:

Journal of Alzheimer's disease IOS Press
Paese di pubblicazione: Paesi Bassi
Lingua: inglese
ISSN: 1387-2877

Numero volume: 24

Numero fascicolo: 1

DOI: 10.3233/JAD-2010-101473

Referee: Sė: Internazionale

URL: http://iospress.metapress.com/content/r474r375hxt67344/

Strutture CNR:

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