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Istituto di scienze e tecnologie della cognizione

Torna all'elenco Contributi in rivista anno 2014

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Inter-hemispheric functional connectivity changes with corpus callosum morphology in multiple sclerosis

Anno di pubblicazione: 2014

Formato: Elettronico

Autori: Zito, G.; Luders, E.; Tomasevic, L.; Lupoi, D.; Toga, A. W.; Thompson, P. M.; Rossini, P. M.; Filippi, M. M.; Tecchio, F.

Affiliazioni autori: Ospedale San Pietro Fatebenefratelli; Ospedale San Pietro Fatebenefratelli; David Geffen School of Medicine at UCLA; IRCCS San Raffaele Pisana; Universita Cattolica del Sacro Cuore, Rome

Autori CNR:


Lingua: inglese

Abstract: Multiple sclerosis (MS) affects myelin sheaths within the central nervous system, concurring to cause brain atrophy and neurodegeneration as well as gradual functional disconnections. To explore early signs of altered connectivity in MS from a structural and functional perspective, the morphology of corpus callosum (CC) was correlated with a dynamic inter-hemispheric connectivity index.Twenty mildly disabled patients affected by a relapsing-remitting (RR) form of MS (EDSS. <=. 3.5) and 15 healthy subjects underwent structural MRI to measure CC thickness over 100 sections and electroencephalography to assess a spectral coherence index between primary regions devoted to hand control, at rest and during an isometric handgrip.In patients, an overall CC atrophy was associated with increased lesion load. A less efficacious inter-hemispheric coherence (IHCoh) during movement was associated with CC atrophy in sections interconnecting homologous primary motor areas (anterior mid-body). In healthy controls, less efficacious IHCoh at rest was associated with a thinner CC splenium.Our data suggest that in mildly disabled RR-MS patients a covert impairment may be detected in the correlation between the structural (CC thickness) and functional (IHCoh) measures of homologous networks, whereas these two counterparts do not yet differ individually from controls. © 2014 IBRO.

Lingua abstract: inglese

Pagine da: 47

Pagine a: 55


Neuroscience Pergamon Press.
Paese di pubblicazione: Regno Unito
Lingua: inglese
ISSN: 0306-4522

Numero volume: 266

DOI: 10.1016/j.neuroscience.2014.01.039

Referee: Sì: Internazionale

Stato della pubblicazione: Published version

Indicizzato da: Scopus [2-s2.0-84896861796]

Parole chiave:

  • Corpus callosum
  • Electroencephalography/event-related potentials (EEG/ERPs)
  • Inter-hemispheric coherence
  • Relapsing-remitting multiple sclerosis (RRMS)
  • Sensorimotor control
  • Structural magnetic resonance imaging

URL: http://www.scopus.com/record/display.url?eid=2-s2.0-84896861796&origin=inward

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