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Istituto di scienze e tecnologie della cognizione

Torna all'elenco Contributi in rivista anno 2014

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Neuroimaging in amyotrophic lateral sclerosis: Insights into structural and functional changes

Anno di pubblicazione: 2014

Autori: Chiò, Adriano; Pagani, Marco; Agosta, Federica; Calvo, Andrea; Cistaro, Angelina; Filippi, Massimo M.

Affiliazioni autori: Universita degli Studi di Torino; Istituto Di Scienze E Tecnologie Della Cognizione, Rome; Universita Vita-Salute San Raffaele; Euromedic Inc; Karolinska University Hospital

Autori CNR:


Lingua: inglese

Abstract: In the past two decades, structural and functional neuroimaging findings have greatly modified longstanding notions regarding the pathophysiology of amyotrophic lateral sclerosis (ALS). Neuroimaging studies have shown that anatomical and functional lesions spread beyond precentral cortices and corticospinal tracts, to include the corpus callosum; frontal, sensory, and premotor cortices; thalamus; and midbrain. Both MRI and PET studies have shown early and diffuse loss of inhibitory cortical interneurons in the motor cortex (increased levels of functional connectivity and loss of GABAergic neurons, respectively) and diffuse gliosis in white-matter tracts. In ALS endophenotypes, neuroimaging has also shown a diverse spreading of lesions and a dissimilar impairment of functional and structural connections. A possible role of PET in the diagnosis of ALS has recently been proposed. However, most neuroimaging studies have pitfalls, such as a small number and poor clinical characterisation of patients, absence of adequate controls, and scarcity of longitudinal assessments. Studies involving international collaborations, standardised assessments, and large patient cohorts will overcome these shortcomings and provide further insight into the pathogenesis of ALS.

Lingua abstract: inglese

Pagine da: 1228

Pagine a: 1240


Lancet neurology Elsevier
Paese di pubblicazione: Paesi Bassi
Lingua: inglese
ISSN: 1474-4422

Numero volume: 13

Numero fascicolo: 12

DOI: 10.1016/S1474-4422(14)70167-X

Referee: Sì: Internazionale

Indicizzato da: Scopus [2-s2.0-84919396489]

Parole chiave:

  • amyotrophic lateral sclerosis
  • PET
  • MRI
  • astrocytosis

URL: http://www.scopus.com/record/display.url?eid=2-s2.0-84919396489&origin=inward

Strutture CNR:


Allegati: 2014 LANCET NEUROLOGY ALS MRI PET (application/pdf)

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