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Istituto di scienze e tecnologie della cognizione

Torna all'elenco Contributi in rivista anno 2014

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Association of central serotonin transporter availability and body mass index in healthy Europeans

Anno di pubblicazione: 2014

Formato: Elettronico Cartaceo

Autori: Hesse, Swen; Van De Giessen, Elsmarieke M.; Zientek, Franziska; Petroff, David; Winter, Karsten; Dickson, John Caddell; Tossici-Bolt, Livia; Sra, Terz; Asenbaum, Susanne; Darcourt, Jacques; Akdemir, mit zgr; Knudsen, Gitte Moos; Nobili, Flavio Mariano; Pagani, Marco; Vander Borght, Thierry M.; Van Laere, Koen Van R; Varrone, Andrea; Tatsch, Klaus; Sabri, Osama; Booij, Jan

Affiliazioni autori: Universitat Leipzig; Universitatsklinikum Leipzig und Medizinische Fakultat; Academic Medical Centre, University of Amsterdam; Centre for Clinical Studies; Translational Centre for Regenerative Medicine (TRM) Leipzig; UCL; Southampton University Hospitals NHS Trust; Szegedi Tudomanyegyetem; Medizinische Universitat Wien; Universite Nice Sophia Antipolis; Gazi Universitesi; Rigshospitalet; Universita degli Studi di Genova; Karolinska University Hospital; Istituto Di Scienze E Tecnologie Della Cognizione, Rome; Universite Catholique de Louvain; University Hospital Leuven; Karolinska Institutet; Ludwig-Maximilians-Universitat Munchen; Municipal Hospital Karlsruhe Inc.

Autori CNR:

  • MARCO PAGANI

Lingua: inglese

Abstract: Serotonin-mediated mechanisms,inparticularviatheserotonintransporter(SERT),arethought to haveaneffectonfoodintakeandplayanimportantroleinthepathophysiologyofobesity. However,imagingstudiesthatexaminedthecorrelationbetweenbodymassindex(BMI)and SERTaresparseandprovidedcontradictoryresults.Theaimofthisstudywastofurthertestthe association betweenSERTandBMIinalargecohortofhealthysubjects. Methods: 127subjects of theENCDATdatabase(58females,age52718 years,range20-83, BMI25.273.8 kg/m2, range 18.2-41.1) wereanalysedusingregion-of-interest(ROI)andvoxel-basedapproachesto calculate [123I]FP-CIT specific-to-nonspecific bindingratios(SBR)inthehypothalamus/thalamus and midbrain/brainstemasSERT-specific targetregions. Results: Inthevoxel-basedanalysis, SERTavailabilityandBMIwerepositivelyassociatedinthethalamus,butnotinthemidbrain. In theROI-analysis,theinteractionbetweengenderandBMIshowedatrendwithhigher correlation coefficient formeninthemidbrainalbeitnotsignificant (0.033SBRm2/kg, p=0.1). Conclusions: ThedataareinagreementwithpreviousPET findings ofanalteredcentral serotonergic tonedependingonBMI,asaprobablepathophysiologicmechanisminobesity,and should encouragefurtherclinicalstudiesinobesitytargetingtheserotonergicsystem.

Lingua abstract: inglese

Pagine da: 1240

Pagine a: 1247

Rivista:

European neuropsychopharmacology Elsevier Science Publishers
Paese di pubblicazione: Paesi Bassi
Lingua: inglese
ISSN: 0924-977X

Numero volume: 24

Numero fascicolo: 8

DOI: 10.1016/j.euroneuro.2014.05.005

Referee: S: Internazionale

Indicizzato da: Scopus [2-s2.0-84905041212]

Parole chiave:

  • 5-HTT
  • BMI
  • FP-CIT
  • Obesity
  • Serotonin
  • SPECT

URL: http://www.scopus.com/record/display.url?eid=2-s2.0-84905041212&origin=inward

Strutture CNR:

Moduli:

Allegati: 2014 ENPP ENC SERT BMI (application/pdf)

 
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