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Istituto di scienze e tecnologie della cognizione

Torna all'elenco Contributi in rivista anno 2014

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Extrastriatal binding of [123I]FP-CIT in the thalamus and pons: gender and age dependencies assessed in a European multicentre database of healthy controls

Anno di pubblicazione: 2014

Formato: Elettronico Cartaceo

Autori: Koch, Walter H.; Unterrainer, Marcus; Xiong, Guoming; Bartenstein, Peter P.; Diemling, Markus; Varrone, Andrea; Dickson, John Caddell; Tossici-Bolt, Livia; Séra, Teréz; Asenbaum, Susanne; Booij, Jan; Kapucu, Özlem Lütfiye; Kluge, Andreas; Ziebell, Morten; Darcourt, Jacques; Nobili, Flavio Mariano; Pagani, Marco; Hesse, Swen; Vander Borght, Thierry M.; Van Laere, Koen Van R; Tatsch, Klaus; La Fougčre, Christian

Affiliazioni autori: Ludwig-Maximilians-Universitat Munchen; Hermes Medical Solutions; Karolinska University Hospital; NHS Foundation Trust; Southampton University Hospitals NHS Trust; Szegedi Tudomanyegyetem; Medizinische Universitat Wien; Academic Medical Centre, University of Amsterdam; Gazi Universitesi; ABX-CRO; Kobenhavns Universitet; Universite Nice Sophia Antipolis; Universita degli Studi di Genova; Istituto Di Scienze E Tecnologie Della Cognizione, Rome; Universitat Leipzig; Universite Catholique de Louvain; Katholieke Universiteit Leuven; Stadtischen Klinikum Karlsruhe; Universitat Tubingen

Autori CNR:

  • MARCO PAGANI

Lingua: inglese

Abstract: Purpose Apart from binding to the dopamine transporter (DAT), [123I]FP-CITshows moderate affinity for the serotonin transporter (SERT), allowing imaging of both monoamine transporters in a single imaging session in different brain areas. The aim of this study was to systematically evaluate extrastriatal binding (predominantly due to SERT) and its age and gender dependencies in a large cohort of healthy controls. Methods SPECT data from 103 healthy controls with welldefined criteria of normality acquired at 13 different imaging centres were analysed for extrastriatal binding using volumes of interest analysis for the thalamus and the pons. Data were examined for gender and age effects as well as for potential influence of striatal DAT radiotracer binding. Results Thalamic binding was significantly higher than pons binding. Partial correlations showed an influence of putaminal DAT binding on measured binding in the thalamus but not on the pons. Data showed high interindividual variation in extrastriatal binding. Significant gender effects with 31 % higher binding in women than in men were observed in the thalamus, but not in the pons. An age dependency with a decline per decade (±standard error) of 8.2±1.3 % for the thalamus and 6.8±2.9 % for the pons was shown. Conclusion The potential to evaluate extrastriatal predominant SERT binding in addition to the striatal DAT in a single imaging session was shown using a large database of [123I]FPCIT scans in healthy controls. For both the thalamus and the pons, an age-related decline in radiotracer binding was observed. Gender effects were demonstrated for binding in the thalamus only. As a potential clinical application, the data could be used as a reference to estimate SERT occupancy in addition to nigrostriatal integrity when using [123I]FP-CIT for DAT imaging in patients treated with selective serotonin reuptake inhibitors.

Lingua abstract: inglese

Pagine da: 1938

Pagine a: 1946

Rivista:

European journal of nuclear medicine and molecular imaging Springer.
Paese di pubblicazione: Germania
Lingua: inglese
ISSN: 1619-7070

Numero volume: 41

DOI: 10.1007/s00259-014-2785-8

Referee: Sě: Internazionale

Indicizzato da: Scopus [2-s2.0-84901552024]

Parole chiave:

  • [object Object]
  • Age effects
  • Dopamine transporter
  • Extrastriatal binding
  • Gender difference
  • Serotonin transporter
  • SPECT

URL: http://www.scopus.com/record/display.url?eid=2-s2.0-84901552024&origin=inward

Strutture CNR:

Moduli:

Allegati: 2014 EJNMMI Extrastriatal FP-CIT ENCDAT (application/pdf)

 
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