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Istituto di scienze e tecnologie della cognizione

Torna all'elenco Contributi in rivista anno 2014

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Towards mapping the brain connectome in depression: Functional connectivity by perfusion SPECT

Anno di pubblicazione: 2014

Formato: Elettronico Cartaceo

Autori: Gardner, Ann P W; Åstrand, Disa; Öberg, Johanna; Jacobsson, Hans; Jonsson, Cathrine E.; Larsson, Stig A.; Pagani, Marco

Affiliazioni autori: Karolinska Institutet; Järva Psychiatric Out-patient Clinic; Karolinska University Hospital; Istituto Di Scienze E Tecnologie Della Cognizione, Rome

Autori CNR:


Lingua: inglese

Abstract: Several studies have demonstrated altered brain functional connectivity in the resting state in depression. However, no study has investigated interregional networking in patients with persistent depressive disorder (PDD). The aim of this study was to assess differences in brain perfusion distribution and connectivity between large groups of patients and healthy controls. Participants comprised 91 patients with PDD and 65 age- and sex-matched healthy controls. Resting state perfusion was investigated by single photon emission computed tomography, and group differences were assessed by Statistical Parametric Mapping. Brain connectivity was explored through a voxel-wise interregional correlation analysis using as covariate of interest the normalized values of clusters of voxels in which perfusion differences were found in group analysis. Significantly increased regional brain perfusion distribution covering a large part of the cerebellum was observed in patients as compared with controls. Patients showed a significant negative functional connectivity between the cerebellar cluster and caudate, bilaterally. This study demonstrated inverse relative perfusion between the cerebellum and the caudate in PDD. Functional uncoupling may be associated with a dysregulation between the role of the cerebellum in action control and of the caudate in action selection, initiation and decision making in the patients. The potential impact of the resting state condition and the possibility of mitochondrial impairment are discussed. © 2014 Elsevier Ireland Ltd.

Lingua abstract: inglese

Pagine da: 171

Pagine a: 177


Psychiatry research. Neuroimaging Elsevier Scientific Publishers Ireland
Paese di pubblicazione: Paesi Bassi
Lingua: inglese
ISSN: 0925-4927

Numero volume: 223

Numero fascicolo: 2

DOI: 10.1016/j.pscychresns.2014.05.008

Indicizzato da: Scopus [2-s2.0-84903820249]

Parole chiave:

  • Caudate
  • Cerebellum
  • Chronic depression
  • Mitochondrial impairment
  • Persistent depressive disorder

URL: http://www.scopus.com/record/display.url?eid=2-s2.0-84903820249&origin=inward

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