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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2009

Contributo in rivista

Tipo: Articolo in rivista

Titolo: GALT Protein Database, a Bioinformatics Resource for the Management and Analysis of Structural Features of a Galactosemia-related Protein and Its Mutants

Anno di pubblicazione: 2009

Formato: Elettronico

Autori: d'Acierno A.; Facchiano A.; Marabotti A.

Affiliazioni autori: Laboratory of Bioinformatics and Computational Biology, Institute of Food Science, Italian National Research Council (CNR), 83100 Avellino, Italy

Autori CNR:


Lingua: inglese

Abstract: We describe the GALT-Prot database and its related web-based application that have been developed to collect information about the structural and functional effects of mutations on the human enzyme galactose-1-phosphate uridyltransferase (GALT) involved in the genetic disease named galactosemia type I. Besides a list of missense mutations at gene and protein sequence levels, GALT-Prot reports the analysis results of mutant GALT structures. In addition to the structural information about the wild-type enzyme, the database also includes structures of over 100 single point mutants simulated by means of a computational procedure, and the analysis to each mutant was made with several bioinformatics programs in order to investigate the effect of the mutations. The web-based interface allows querying of the database, and several links are also provided in order to guarantee a high integration with other resources already present on the web. Moreover, the architecture of the database and the web application is flexible and can be easily adapted to store data related to other proteins with point mutations. GALT-Prot is freely available at http://bioinformatica.isa.cnr.it/GALT/.

Lingua abstract: inglese

Pagine da: 71

Pagine a: 76


Genomics, Proteomics & Bioinformatics Science Press.
Paese di pubblicazione: Cina
Lingua: inglese
ISSN: 1672-0229

Numero volume: 7

Numero fascicolo: 1-2

DOI: 10.1016/S1672-0229(08)60035-2

Referee: Sì: Internazionale

Indicizzato da:

  • Scopus [2-s2.0-67649666838]
  • PubMed [19828085]

Parole chiave:

  • database
  • mutation
  • homology modeling
  • galactosemia
  • GALT enzyme

Strutture CNR:


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