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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2010

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Phytochemicals in Cancer Prevention and Therapy: Truth or Dare ?

Anno di pubblicazione: 2010

Formato: Elettronico Cartaceo

Autori: Russo, M. Spagnuolo, C. Tedesco, I. Russo, G. L.

Affiliazioni autori: Istituto Scienze dell'Alimentazione

Autori CNR:

  • GIAN LUIGI RUSSO
  • MARIA RUSSO
  • IDOLO TEDESCO

Lingua: inglese

Abstract: A voluminous literature suggests that an increase in consumption of fruit and vegetables is a relatively easy and practical strategy to reduce significantly the incidence of cancer. The beneficial effect is mostly associated with the presence of phytochemicals in the diet. This review focuses on a group of them, namely isothiocyanate, curcumin, genistein, epigallocatechin gallate, lycopene and resveratrol, largely studied as chemopreventive agents and with potential clinical applications. Cellular and animal studies suggest that these molecules induce apoptosis and arrest cell growth by pleiotropic mechanisms. The anticancer efficacy of these compounds may result from their use in monotherapy or in association with chemotherapeutic drugs. This latter approach may represent a new pharmacological strategy against several types of cancers. However, despite the promising results from experimental studies, only a limited number of clinical trials are ongoing to assess the therapeutic efficacy of these molecules. Nevertheless, the preliminary results are promising and raise solid foundations for future investigations.

Lingua abstract: inglese

Pagine da: 517

Pagine a: 551

Rivista:

Toxins MDPI
Paese di pubblicazione:
Lingua: inglese
ISSN: 2072-6651

Numero volume: 2

DOI: 10.3390/toxins2040517

Referee: Sė: Internazionale

Indicizzato da:

  • PubMed [22069598]
  • Scopus [2-s2.0-79952096877]

Altre informazioni: Free access at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153217/?tool=pubmed

Strutture CNR:

Moduli:

Allegati: Toxins 2010, 2, 517-551 (application/pdf)

 
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