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Contributo in rivista
Tipo: Articolo in rivista
Titolo: The flavonoid quercetin in disease prevention and therapy: Facts and fancies.
Anno di pubblicazione: 2012
Formato: Elettronico Cartaceo
Autori: Russo M, Spagnuolo C, Tedesco I, Bilotto S, Russo GL.
Affiliazioni autori: Istituto Scienze dell'Alimentazione
Abstract: Abstract Biochemical and genetic studies on cellular and animal models on the mechanism(s) of action of phytochemicals provide a functional explanation of how and why a diet rich in fruits and vegetables is considered healthy. It is not unusual to find molecules that protect against diseases, which greatly differ from a physiopathological point of view, such as cancer and cardiovascular disorders. Quercetin falls into this category and possesses a broad range of biological properties. Uptake, metabolism and circulating concentrations of quercetin and its metabolites suggest that a regular diet provides amounts of quercetin (<1¼M) not compatible with its chemopreventive and/or cardioprotective effects. However, it appears relatively easy to increase total quercetin concentrations in plasma (>10¼M) by supplementation with quercetin-enriched foods or supplements. Multiple lines of experimental evidence suggest a positive association between quercetin intake and improved outcomes of inflammatory cardiovascular risk. The ameliorating effect of quercetin administration can be extended to other chronic inflammatory disorders but only if supplementation occurs in patients. Quercetin can be considered the prototype of a naturally-occurring chemopreventive agent because of its key roles in triggering the "hallmarks of cancer". However, several critical points must be taken into account when considering the potential therapeutic use of this molecule: (1) pharmacological versus nutraceutical doses applied, (2) specificity of its mechanism of action compared to other phytochemicals, and (3) identification of "direct" cellular targets. The design of specific clinical trials is extremely warranted to depict possible applications of quercetin in adjuvant cancer therapy. Copyright © 2011 Elsevier Inc. All rights reserved.
Lingua abstract: inglese
Pagine da: 6
Pagine a: 15
Numero volume: 83
Numero fascicolo: 1
Referee: Sì: Internazionale
Altre informazioni: Pubmed link: http://www.ncbi.nlm.nih.gov/pubmed/21856292 Epub 2011 Aug 16. On April 30, 2012 it resulted the 20th Most Downloaded Biochemical Pharmacology Article
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