Home |  English version |  Mappa |  Commenti |  Sondaggio |  Staff |  Contattaci Cerca nel sito  
Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2012

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Cellular adaptive response to chronic radiation exposure in interventional cardiologists

Anno di pubblicazione: 2012

Formato: Elettronico Cartaceo

Autori: Russo, Gian Luigi (3); Idolo, Tedesco (3); Russo, Maria (3); Cioppa, Angelo (2); Andreassi, Maria Grazia (1); Picano, Eugenio (1);

Affiliazioni autori: (1) CNR-IFC, Pisa; (2) Clinica Montevergine, Mercogliano, Italy; (3) Institute of Food Sciences, National Research Council, Avellino, Italy

Autori CNR:


Lingua: inglese

Abstract: Aims Invasive cardiologists are the most exposed to ionizing radiation among health professionals and show an increased rate of somatic DNA damage. To evaluate the effects of chronic low-dose exposure to ionizing radiation on redox state and apoptotic activation. Methods and results We enrolled 10 healthy exposed professionals (all interventional cardiologists, Group II, exposed: age = 38 5 years) and 10 age- and gender-matched unexposed controls (Group I, non-exposed). Exposed subjects had a median exposure of 4 mSv/year (range 1-8) by film badge dosimetry (below lead apron). We measured reduced glutathione (GSH, a marker of antioxidant response) in erythrocytes and plasma generation of hydrogen peroxide (a marker of oxyradical stress) by ferrous oxidation-xylenol orange assay in plasma. In both groups, lymphocytes were isolated and caspase-3 activity (a marker of apoptotic response) measured at baseline and following 2 Gy in vitro irradiation. Exposed subjects showed a three-fold increase in hydrogen peroxide (Group I = 2.21 1.03 vs. II = 6.51 1.55 M H(2)O(2) equivalents) and a 1.7-fold increase in GSH (I = 12.37 1.22 vs. II = 20.61 2.16 mM). Exposed subjects also showed higher values of caspase-3 activity, both at baseline and-more strikingly-following high-dose radiation challenge. Conclusion In interventional cardiologists, chronic exposure to low-dose radiation is associated with an altered redox balance mirrored by an increase in hydrogen peroxide and with two possibly adaptive cellular responses: (i) an enhanced antioxidant defence (increase in GSH, counteracting increased oxyradical stress) and (ii) an increased susceptibility to apoptotic induction which might efficiently remove genetically damaged cells.

Lingua abstract: inglese

Pagine da: 408

Pagine a: 414


European heart journal Academic Press,
Paese di pubblicazione: Regno Unito
Lingua: inglese
ISSN: 0195-668X

Numero volume: 33

Numero fascicolo: 3

DOI: 10.1093/eurheartj/ehr263

Referee: S: Internazionale

Indicizzato da:

  • PubMed [21862464]
  • ISI Web of Science (WOS) [000300046100021]
  • Scopus [2-s2.0-84856728957]

Parole chiave:

  • low dose radiation
  • cardiologist
  • antioxidant
  • redox balance

Altre informazioni: ID_PUMA: cnr.ifc/2011-A0-125. - First published online: cnr.ifc/2011-A0-125. - First published online: August 23, 2011. - Descrizione sintetica del prodotto: Abstract link: http://www.ncbi.nlm.nih.gov/pubmed/21862464.

Strutture CNR:


Torna indietro Richiedi modifiche Invia per email Stampa
Home Il CNR  |  I servizi News |   Eventi | Istituti |  Focus