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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2011

Contributo in rivista

Tipo: Articolo in rivista

Titolo: A possible predictive marker of progression for hepatocellular carcinoma

Anno di pubblicazione: 2011

Formato: Cartaceo

Autori: Di Stasio M; Volpe MG; Colonna G; Nazzaro M; Polimeno M; Scala S; Castello G; Costantini S

Affiliazioni autori: Institute of Food Sciences, CNR; Department of Biochemistry and Biophysics and Interdepartmental Research Center for Computational and Biotechnological Sciences (CRISCEB), Second University of Naples; G. Pascale Foundation National Cancer Institute, Naples; G. Pascale Foundation National Cancer Institute, Cancer Research Center, Mercogliano, Avellino

Autori CNR:

  • MICHELE DI STASIO
  • MARIA GRAZIA VOLPE

Lingua: inglese

Abstract: The correlation between decreased levels of selenium and increased DNA damage and oxidative stress shows the significance of this trace element. A number of studies have provided evidence for lower serum, plasma and tissue levels of selenium in patients with various diseases and types of cancer. In this study, liver selenium concentrations were measured in tissue samples of patients with hepatocellular carcinoma (HCC) by atomic absorption spectrometry. The results showed that the selenium concentrations decreased when the malignant grade increased. Furthermore, a significant correlation was found between selenium levels and human selenium binding protein-1 (SELENBP1) down-regulation in the liver. Therefore, we suggest that the evaluation of selenium and SELENBP1 concentrations can be used for improving the prognosis of HCC.

Lingua abstract: inglese

Pagine da: 1247

Pagine a: 1251

Rivista:

Oncology Letters Ekdoseis A. Spantidos
Paese di pubblicazione: Grecia
Lingua: inglese
ISSN: 1792-1074

Numero volume: 2

Numero fascicolo: 6

DOI: 10.3892/ol.2011.378

Referee: Sì: Internazionale

Stato della pubblicazione: Published version

Indicizzato da:

  • ISI Web of Science (WOS) [000295390800037]
  • Scopus [7782-49-2]

Parole chiave:

  • selenium
  • selenium binding protein-1
  • hepatocarcinoma prognosis
  • atomic absorption spectrometry
  • HCC marker

URL: http://www.spandidos-publications.com/10.3892/ol.2011.378

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