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Contributo in rivista
Tipo: Articolo in rivista
Titolo: Type 2 diabetes mellitus is characterized by reduced postprandial adiponectin response: a possible link with diabetic postprandial dyslipidemia.
Anno di pubblicazione: 2010
Formato: Elettronico Cartaceo
Autori: Annuzzi G; Bozzetto L; Patti L; Santangelo C; Giacco R; Di Marino L; De Natale C; Masella R; Riccardi G; Rivellese AA.
Affiliazioni autori: Department of Clinical and Experimental Medicine, Federico II University, 80131 Naples, Italy Centre for Food Quality and Risk Assessment, National Institute of Health, 00161 Rome, Italy Institute of Food Science, CNR, 83100 Avellino, Italy
Abstract: We investigated postprandial plasma and adipose tissue (AT) adiponectin changes in relation to obesity and type 2 diabetes mellitus. Fasting and 6 hours after a standard fat-rich meal blood samples (adiponectin, glucose, insulin, lipids) and needle biopsies of abdominal subcutaneous AT (adiponectin messenger RNA, lipoprotein lipase activity) were taken in 10 obese diabetic (OD), 11 obese nondiabetic (OND), and 11 normal-weight control (C) men. The OD and OND subjects had similar adiposity (body mass index, waist circumference) and insulin resistance (hyperinsulinemic euglycemic clamp). Fasting plasma adiponectin and AT gene expression were not significantly different between groups. After meal, plasma adiponectin decreased in OD but significantly increased in OND and C, the changes being significantly different between groups (analysis of variance, P = .01); adiponectin messenger RNA decreased in OD (-0.27 ▒ 0.25 AU, P = .01) but was unchanged in OND (P = .59) and C (P = .45). After meal, plasma adiponectin correlated inversely with triglyceride and cholesterol concentrations in chylomicrons and large very low-density lipoprotein, and directly with AT lipoprotein lipase activity (P < .05 for all). Type 2 diabetes mellitus is associated with lower postprandial plasma levels and AT gene expression of adiponectin independently of degree of adiposity and whole-body insulin sensitivity. In patients with diabetes, this may exacerbate postprandial abnormalities of lipoprotein metabolism.
Lingua abstract: inglese
Pagine da: 567
Pagine a: 574
Metabolism, clinical and experimental
W.B. Saunders Co. [etc.]
Numero volume: 59
Numero fascicolo: 4
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