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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2010

Contributo in rivista

Tipo: Articolo in rivista

Titolo: 3D Modelling of Three Pro-Inflammatory Molecules in Selected Fish Species.

Anno di pubblicazione: 2010

Autori: Costantini S, Facchiano AM, Randelli E, Casani D, Scapigliati G, Buonocore F.

Affiliazioni autori: Department of Environmental Sciences, University of Tuscia, Largo dell'UniversitÓ S.N.C., I-01100 Viterbo, Italy. Istituto di Scienza dell'Alimentazione, CNR, Avellino

Autori CNR:


Lingua: inglese

Abstract: The inflammatory response is the reaction of all Metazoan organisms to pathogen invasion that initiates when pathogenderived molecules are recognized by specific pattern recognition receptors expressed mainly on cells of the innate immune system. The successive expression of pro-inflammatory cytokines and chemokines limits pathogen spread, and attracts and activates immune cells to help in the elimination of the invaders. In this paper we focused on the analyses of the 3D structures of three pro-inflammatory molecules (interleukin-1?, tumor necrosis factor-?, interleukin-8) from selected Teleost fish species (Oncorhynchus mykiss, Dicentrarchus labrax, Chionodraco hamatus) generated using as template models those of experimental homologous proteins. These structures were discussed with the aim to investigate the differences between them and mammalian counterparts and, moreover, to verify the presence of the structural requirements for their biological activities, known mainly in mammals.

Lingua abstract: inglese

Pagine da: 4203

Pagine a: 4212


Current pharmaceutical design Bentham Science Publishers
Paese di pubblicazione: Paesi Bassi
Lingua: inglese
ISSN: 1381-6128

Numero volume: 16

Indicizzato da: PubMed [21184658]

URL: http://www.benthamdirect.org/pages/content.php?CPD/2010/00000016/00000038/0007B.SGM

Altre informazioni: PMID: 21184658

Strutture CNR:


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