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Contributo in rivista
Tipo: Articolo in rivista
Titolo: Gender differences in copper, zinc and selenium status in diabetic-free metabolic syndrome European population - The IMMIDIET study
Anno di pubblicazione: 2010
Autori: Arnaud J; de Lorgeril M; Akbaraly T; Salen P; Arnout J; Cappuccio FP; van Dongen MC; Donati MB; Krogh V; Siani A; Iacoviello L; on behalf of the EuropeanCollaborative Group of the IMMIDIET Project.
Affiliazioni autori: Inserm, U 884, Bioe´nerge´tique Fondamentale et Applique´e, BP 53X, Grenoble Cedex 9, F38041 France Departement de Biochimie, Toxicologie et Pharmacologie, Pole de Biologie, CHU de Grenoble, BP 217, 38043 Grenoble Cedex 9, France Laboratoire Coeur et Nutrition, TIMC-IMAG-CNRSUMR5525, Faculte´de medecine,Domaine de lMerci, 38710 LaTronche, France Inserm, U 888, Pathologies du systeme nerveux: recherche epidemiologique et clinique; Universite´ Montpellier I. Hopital La Colombiere, 39 avenue Charles Flahault, BP 34493, Montpellier Cedex 5, F34093, France Department of Epidemiology and Public Health, University College London, WC1E 6BT, United Kingdom Centre for Molecular and Vascular Biology, Katholieke Universiteit Leuven, O&N I Herestraat 49, 3000 Leuven, Belgium Clinical Sciences Research Institute,Warwick Medical School, The University ofWarwick, Coventry CV4 7AL, United Kingdom Department of Epidemiology, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands Catholic University, Laboratory of Genetic and Environmental Epidemiology, Research Laboratories, 'John Paul II' Centre for High Technology Research and Education in Biomedical Sciences, Largo Gemelli 1, 86100 Campobasso, Italy Nutritional Epidemiology Unit, National Cancer Institute, Via Venezian, 1, 20133 Milan, Italy Unit of Epidemiology & Population Genetics, Institute of Food Sciences CNR, Via Roma 64, 83100 Avellino, Italy
Abstract: BACKGROUND AND AIMS: The European 'IMMIDIET' study was designed to evaluate the effect of genetic and dietary habit interactions on cardiovascular disease risk factors in non-diabetic subjects. Copper, zinc and selenium are involved in redox balance and modifications of their homeostasis could be associated with metabolic syndrome. Because few studies have dealt with trace element status in metabolic syndrome with conflicting results, we aimed at investigating the relationships between plasma copper, zinc and selenium concentrations and metabolic syndrome in the IMMIDIET population. METHODS AND RESULTS: Male-female couples born and living in Abruzzo, Italy (n = 271); Limburg, Belgium (n = 267), southwest part of London, England (n = 263) and 205 Italian-Belgian mixed couples living in Belgium were enrolled. Data on medical history, hypertension and blood lipid profile, medication use, smoking and alcohol habits, physical activity and socioeconomic status were collected using a standardised questionnaire. Anthropometric, blood pressure, glucose, insulin, lipid profile and copper, zinc and selenium measurements were performed. Participants were classified in two groups according to the presence of metabolic syndrome (Yes/No). Comparison between these two groups, performed separately in men and women, indicated no association in men whereas, in women, metabolic syndrome was associated with higher plasma selenium concentrations (odds ratio (OR) = 1.55(1.28-1.89)); this association remained significant after adjustment for age, group, social status, physical activity, energy intake, alcohol consumption, smoking and hormonal status (OR = 1.33 (1.06-1.67)). CONCLUSION: Our results indicate gender differences in the association between plasma selenium concentration and metabolic syndrome without diabetes and may suggest a sub-clinical deleterious effect of high selenium status in women.
Lingua abstract: inglese
NMCD. Nutrition Metabolism and Cardiovascular Diseases
Referee: Sì: Internazionale
Indicizzato da: PubMed 
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