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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2011

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Influence of sample collection and pre-analytical sample processing on the analyses of biological markers in the European multicentre study IDEFICS

Anno di pubblicazione: 2011

Autori: Peplies J, Guenther K, Bammann K, Fraterman A, Russo P, Veidebaum T, Tornaritis M, Vanaelst B, Marild S, Molnar D, Moreno LA, and Ahrens W on behalf of the IDEFICS consortium

Affiliazioni autori: Univ Bremen, Bremen Inst Prevent Res & Social Med, D-28359 Bremen, Germany [ 2 ] MVZ Dortmund Dr Eberhard & Partner, Dortmund, Germany Show the Organization-Enhanced name(s) [ 3 ] CNR, Inst Food Sci, Avellino, Italy Show the Organization-Enhanced name(s) [ 4 ] Natl Inst Hlth Dev, Tallinn, Estonia [ 5 ] Res & Educ Inst Child Hlth, Strovolos, Cyprus Show the Organization-Enhanced name(s) [ 6 ] Univ Ghent, Dept Publ Hlth, B-9000 Ghent, Belgium [ 7 ] Queen Silvia Childrens Hosp, Dept Publ Hlth & Community Med, Gothenburg, Sweden Show the Organization-Enhanced name(s) [ 8 ] Univ Pecs, Natl Inst Hlth Promot, Pecs, Hungary Show the Organization-Enhanced name(s) [ 9 ] Univ Zaragoza, Sch Hlth Sci, Growth Exercise Nutr & Dev Res Grp, Zaragoza, Spain

Autori CNR:

  • PAOLA RUSSO

Lingua: inglese

Abstract: Objective: To evaluate the influence of a standardised sampling protocol and process quality across the different IDEFICS (Identification and prevention of dietary- and lifestyle-induced health effects in children and infants) centres on the results of the biochemical measurements. Design: Baseline survey within the community-based intervention study. Subjects: A total of 16 224 children, aged 2-8 years, enrolled in the IDEFICS baseline survey in 8 European countries. Venous or capillary blood samples were collected from 12 430 children, urine samples from 13 890 children and saliva samples from 14 019 children. Methods: A set of quality indicators was recorded for the biological blood, urine and saliva samples collected during the IDEFICS study. Results of blood and urine measurements were analysed and stratified by selected quality indicators. Results: Concentrations of biological markers in blood and urine measured during the IDEFICS baseline survey are associated with several quality indicators assessed in this study. Between-country variations of these biomarkers are described. It was confirmed that fasting has a big influence on the concentration of certain biomarkers. Biomarkers in morning urine samples may be erroneous if the study subjects void during the night or if samples are not taken from the very first morning urine. Conclusions: The analysed data underline that a standardised sampling protocol is of major importance, especially in multicentre studies, but non-compliance is ever present in spite of well-defined standard operation procedures. Deviations from the protocol should therefore always be documented to avoid error pertaining to the concentration of biological markers.

Lingua abstract: inglese

Pagine da: S104

Pagine a: 112

Rivista:

International journal of obesity Macmillan, Nature Publishing
Paese di pubblicazione: Regno Unito
Lingua: inglese
ISSN: 0307-0565

Numero volume: 35

DOI: 10.1038/ijo.2011.41

Referee: Ś: Internazionale

Indicizzato da: ISI Web of Science (WOS) [000289515100013]

Parole chiave:

  • biological marker
  • biological sample
  • multicenter study
  • IDEFICS

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