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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2010

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Quality management for the collection of biological samples in multicentre studies

Anno di pubblicazione: 2010

Autori: Peplies J; Fraterman A; Scott R; Russo P, Bammann K

Affiliazioni autori: Bremen Institute for Prevention Research and Social Medicine, University of Bremen, Bremen, Germany; Laboratoriumsmedizin Dr. Eberhard und Partner, Dortmund, Germany; MRC Epidemiology Unit, Institute of Metabolic Science, Cambridege, England; Unit of Epidemiology & Population Genetics, institute of Food Sciences, CNR, Avellino, Italy

Autori CNR:

  • PAOLA RUSSO

Lingua: inglese

Abstract: Large scale international multicentre studies require sophisticated quality management for the collection, processing and logistics of biological samples to ensure a maximum degree of standardisation across different environmental conditions and settings. This paper describes a quality management system for the collection of biological samples (QMS-BS) which was applied during IDEFICS, a large European multicentre study. The application was evaluated by several criteria like response rates for the different types of biological samples, measures of sample quality, compliance with the QMS-BS and efficiency of the document and sample control and of the quality assurance system. Response rates varied from 56.6% for venous blood collection to 90.1% for saliva collection. All sample types were associated with problems of sample quality (e.g. haemolysis of blood samples, lack of cooling for urine samples or desiccation of saliva samples). Overall compliance with the QMS-BS was good, with some exceptions mainly related to sample control. In conclusion the QMS-BS is a valuable tool for the management of biological sample collection in epidemiological multicentre studies.

Lingua abstract: inglese

Pagine da: 607

Pagine a: 617

Rivista:

European journal of epidemiology Tipografia La Commerciale
Paese di pubblicazione: Italia
Lingua: inglese
ISSN: 0393-2990

Numero volume: 25

DOI: 10.1007/s10654-010-9481-1

Referee: Ś: Internazionale

Indicizzato da: ISI Web of Science (WOS) [000282102200002]

Parole chiave:

  • Quality management
  • Survey
  • Multicentre study
  • Biological specimen bank
  • Sample database

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