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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2009

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Alcohol consumption and n-3 polyunsaturated fatty acids in healthy men and women from 3 European populations.

Anno di pubblicazione: 2009

Autori: di Giuseppe R; de Lorgeril M; Salen P; Laporte F; Di Castelnuovo A; Krogh V; Siani A; Arnout J; Cappuccio FP; van Dongen M; Donati MB; de Gaetano G; Iacoviello L; on behalf of the European Collaborative Group of the IMMIDIET Project.

Affiliazioni autori: Laboratory of Genetic and Environmental Epidemiology,Research Laboratories, ''John Paul II'' Centre for High Technology Research and Education in Biomedical Sciences, Catholic University, Campobasso, Italy; Unite´ Mixte de Recherche 5525, Centre National deRecherche ScientifiqueUniversite´ Joseph Fourier, Techniques de l'Ingenierie Medicale et de la Complexite´-Informatique, Mathematiques et Applications de Grenoble, Physiologie Respiratoire Experimentale Theorique et Appliquee, Coeur & Nutrition, Faculte´ de Medecine, La Tronche, France; Nutritional Epidemiology Unit, National Cancer Institute, Milan, Italy; Unit of Epidemiology and Population Genetics, Institute of Food Sciences, CNR, Avellino, Italy; Centre for Molecular and Vascular Biology, Katholieke Universiteit, Leuven, Belgium; Clinical Sciences Research Institute,Warwick Medical School, Coventry, United Kingdom; Department of Epidemiology,Maastricht University, Maastricht, Netherlands

Autori CNR:

  • GIANVINCENZO BARBA
  • PAOLA RUSSO
  • ALFONSO SIANI

Lingua: inglese

Altro abstract: Background: Because high dietary and blood n-3 (omega-3) fatty acids (FAs) are protective against coronary heart disease and sudden cardiac death, the alcohol-associated increase in blood n-3 FAs could be considered an original mechanism of alcohol's cardioprotective effect. Objective: Our objective was to assess whether alcohol consumption is associated with concentrations of very-long-chain ''marine'' (eg, fish oil) n-3 FAs both in plasma and in red blood cell membranes. Design: In the framework of the IMMIDIET (Dietary Habit Profile in European Communities with Different Risk of Myocardial Infarction: the Impact of Migration as a Model of Gene-Environment Interaction) Project, 1604 subjects (802 women-men pairs), aged 26-65 y, were enrolled in Italy, Belgium, and England. A 1-y-recall food-frequency questionnaire was used to evaluate dietary intake. Results: In fully adjusted multivariate analyses, alcohol intake was positively associated with plasma eicosapentaenoic acid (EPA), docosahexanoic acid (DHA), and EPA 1 DHA concentrations (P , 0.0001, P¼0.036, and P¼0.002, respectively) in women and with EPA and the EPA 1 DHA index in red blood cells (P , 0.0001 and P ¼ 0.037, respectively). In men, only plasma and red blood cell EPA concentrations were associated with alcohol intake (P ¼ 0.003 and P ¼ 0.004, respectively). Stratified analyses showed an association between alcohol and both plasma and red cell EPA (P ¼0.008 and P¼0.002, respectively),DHA(P ¼0.014 and P¼ 0.008, respectively), and the EPA 1 DHA index (P ¼ 0.010 and P ¼ 0.006, respectively) in wine drinkers, whereas no association was found in those who drink beer and spirits. Conclusions: Alcohol intake was associated with higher plasma and red blood cell concentrations of marine n-3 FAs. Components of wine other than alcohol (polyphenols) might exert these effects. Part of the alcohol-induced cardioprotection may be mediated through increased marine n-3 FAs.

Lingua altro abstract: inglese

Pagine da: 354

Pagine a: 362

Rivista:

The American journal of clinical nutrition Journal of Clinical Nutrition,
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 0002-9165

Numero volume: 89

DOI: 10.3945/ajcn.2008.26661

Referee: Sì: Internazionale

Indicizzato da: ISI Web of Science (WOS) [000262262300045]

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