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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2010

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Commentary on ‘Resveratrol commonly displays hormesis: Occurrence and biomedical significance’

Anno di pubblicazione: 2010

Formato: Elettronico Cartaceo

Autori: I. Tedesco, M. Russo, and G. L. Russo.

Affiliazioni autori: Istituto Scienze dell'Alimentazone, CNR, Avellino

Autori CNR:

  • GIAN LUIGI RUSSO
  • MARIA RUSSO
  • IDOLO TEDESCO

Lingua: inglese

Abstract: The review by Calabrese et al. describes the hormetic dose responses induced by phytoalexin resveratrol in a wide range of biological models. We agree and support the authors’ strategy to present an impressive number of experiments furnished with an exhaustive bibliography to emphasize that many effects induced by resveratrol are dependent on dose and that opposite effects occur at low and high doses, being indicative of a hormetic dose response.’ We also highly appreciate the holistic view of the hormetic behavior of resveratrol provided by the authors spanning from tumor and non-tumor cell lines to human and parasitic diseases. In our comments, we touched minor points whose discussion would have strengthened the work of Calabrese, such as contradictions on the role of resveratrol in the ‘French Paradox,’ its effect on aromatase activity, glutamate cysteine ligase expression and glutathione levels. Overall, we encourage colleagues working in this field to read the present review and consider its relevant biological implications. The vision of Calabrese et al. is far too important to be ignored.

Lingua abstract: inglese

Pagine da: 1020

Pagine a: 1031

Rivista:

Human & experimental toxicology Sage
Paese di pubblicazione: Regno Unito
Lingua: inglese
ISSN: 0960-3271

Numero volume: 29

Numero fascicolo: 12

DOI: 10.1177/0960327110383628

Referee: Sì: Internazionale

Indicizzato da:

  • ISI Web of Science (WOS) [000284762600008]
  • PubMed [21115565]

Altre informazioni: Comparso anche su: BELLE NEWS LETTER Biological Effects of Low Level Exposures A Publication for the Northeast Regional Environmental Public Health Center, University of Massachusetts, School of Public Health, Amherst, MA 01003Vol. 16 No. 2, August 2010, ISSN 1092-4736

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