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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2010

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Phenolic compound characterisation and antiproliferative activity of ‘‘Annurca” apple, a southern Italian cultivar

Anno di pubblicazione: 2010

Formato: Elettronico Cartaceo

Autori: Mari A.; Tedesco I.; Nappo A.; Russo G. L.; Malorni A.; Carbone, V.

Affiliazioni autori: Proteomic and Biomolecular Mass Spectrometry Center, Institute of Food Sciences, National Research Council, Via Roma, 64, 83100 Avellino, Italy BJ Laboratory, Institute of Food Sciences, National Research Council, Via Roma, 64, 83100 Avellino, Italy

Autori CNR:


Lingua: inglese

Abstract: In Annurca apples, a southern Italian variety, polyphenols were studied. The phenolic composition of Annurca apple peel was determined by HPLC coupled with electrospray negative ionisation multistage ion trap mass spectrometry (HPLC/ESI-ITMSn). In addition, the antiproliferative and pro-apoptotic activities of peel extracts enriched in polyphenols and prepared from Annurca (APE), Red Delicious (RDPE) and Golden Delicious (GPE) varieties were evaluated on an HL-60 cell line. APE exhibited the highest total phenol content among the three apple cultivars tested, as determined by Folin-Ciocalteau's procedure and HPLC-UV analysis. APE also showed higher amounts of chlorogenic acid, procyanidins, flavonols, dihydrochalcones and cyanidin-3-O-galactoside than GPE or RDPE. All three apple extracts were able to significantly decrease cell viability, from 50% to 80%, with APE appearing the most effective, while GPE was the least cytotoxic among the three samples. Similarly, APE and RDPE induced a significant increase of caspase-3 activity, whose activation represents a hallmark of apoptosis.

Pagine da: 157

Pagine a: 164


Food chemistry Applied Science Publishers.
Paese di pubblicazione: Regno Unito
Lingua: inglese
ISSN: 0308-8146

Numero volume: 123

DOI: 10.1016/j.foodchem.2010.04.023

Referee: Sì: Internazionale

Indicizzato da:

  • ISI Web of Science (WOS) [000279390900022]
  • Scopus [2-s2.0-77952585963]

Parole chiave:

  • Annurca apple
  • Polyphenols
  • Apoptosis
  • Mass spectrometry

Strutture CNR:


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