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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2008

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Effects of monounsaturated vs. saturated fat on postprandial lipemia and adipose tissue lipases in type 2 diabetes.

Anno di pubblicazione: 2008

Formato: Elettronico Cartaceo

Autori: Rivellese AA; Giacco R; Annuzzi G; De Natale C; Patti L; Di Marino L; Minerva V; Costabile G; Santangelo C; Masella R; Riccardi G.

Affiliazioni autori: Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy Institute of Food Science, CNR, Avellino, Italy National Centre for Food Quality and Risk Assessment, Istituto Superiore di Sanità, Rome, Italy

Autori CNR:

  • ROSALBA GIACCO
  • GABRIELE RICCARDI

Lingua: inglese

Abstract: BACKGROUND: The effects of different dietary fatty acids on postprandial lipid metabolism in type 2 diabetic patients are still debated. AIM: To evaluate the effects of monounsaturated (MUFA) vs. saturated fat (SAFA)-rich diets on postprandial lipemia and adipose tissue lipoprotein lipase (LPL), and hormone-sensitive lipase (HSL) in type 2 diabetes. MATERIALS AND METHODS: Eleven type 2 diabetic patients followed, in random order, a diet rich in MUFA (SAFA 8%, MUFA 23%) and another rich in SAFA (SAFA 17%, MUFA 15%) for a period of 3 weeks each. At the end of the two diets, a standard fat-rich meal was administered and subcutaneous fat biopsies were performed at fasting and 6h after the test meal. RESULTS: Neither diet induced significant changes in meal lipid tolerance, except for a faster (at 2h) increase in chylomicron triglycerides and a significant decrease in small VLDL triglyceride incremental area after the MUFA diet (-13.6+/-4.7 mg/dl*6h vs. -2.2+/-3.7 mg/dl*6h, p<0.005) (M+/-SEM). LPL and HSL activities were significantly increased after the MUFA diet. CONCLUSIONS: A MUFA-rich diet reduces postprandial small VLDL triglycerides in type 2 diabetic patients compared to a SAFA-rich diet, and modifies lipolytic enzymes in adipose tissue.

Lingua abstract: inglese

Pagine da: 133

Pagine a: 141

Rivista:

Clinical nutrition Churchill Livingstone.
Paese di pubblicazione: Regno Unito
Lingua: inglese
ISSN: 0261-5614

Numero volume: 27

Numero fascicolo: 1

DOI: 10.1016/j.clnu.2007.07.005

Referee: Ś: Internazionale

Indicizzato da: ISI Web of Science (WOS) [000254373200017]

Parole chiave:

  • Type 2 diabetes
  • Dietary fat
  • Postprandial lipoproteins
  • Insulin resistance
  • Adipose tissue lipases

Strutture CNR:

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