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Contributo in rivista
Tipo: Articolo in rivista
Titolo: Gliadin regulates the NK-dendritic cell cross-talk by HLA-E surface stabilization.
Anno di pubblicazione: 2007
Autori: Terrazzano G; Sica M; Gianfrani C; Mazzarella G; Maurano F; De Giulio B; de Saint-Mezard S; Zanzi D; Maiuri L; Londei M; Jabri B; Troncone R; Auricchio S; Zappacosta S; Carbone E.
Affiliazioni autori: Department of Cellular and Molecular Biology and Pathology, University Federico II, Naples, Italy; Institute of Food Science and Technology, Consiglio Nazionale delle Ricerche, Avellino, Italy; Department of Pathology, University of Chicago, Chicago, IL 60607; Department of Pediatrics and European Laboratory for the Investigation of Food-Induced Diseases, University Federico II, Naples, Italy; Institute of Child Health, University College London, London, United Kingdom; Department of Experimental and Clinical Medicine University "Magna Graecia," Catanzaro, Italy; Research Center for Studies of Integrative Recognition in the Immune System, Karolinska Institutet, Stockholm, Sweden; Microbiology and Tumorbiology Centre, Karolinska Institutet, Stockholm, Sweden
Abstract: We analyzed the autologous NK cell interaction with gliadin-presenting dendritic cells. Gliadin is the known Ag priming the celiac disease (CD) pathogenesis. We demonstrate that gliadin prevents immature dendritic cells (iDCs) elimination by NK cells. Furthermore, cooperation between human NK cells-iDCs and T cells increases IFN- production of anti-gliadin immune response. Gliadin fractions were analyzed for their capability to stabilize HLA-E molecules. The and fractions conferred the protection from NK cell lysis to iDCs and increased their HLA-E expression. Gliadin pancreatic enzyme digest and a peptide derived from gliadin increased HLA-E levels on murine RMA-S/HLA-E-transfected cells. Analysis of HLA-E expression in the small intestinal mucosa of gluten-containing diet celiac patients and organ culture experiments confirmed the in vitro data.
Lingua abstract: inglese
Pagine da: 372
Pagine a: 382
The Journal of immunology
Williams & Wilkins,
Numero volume: 179
Indicizzato da: ISI Web of Science (WOS) 
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