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Contributo in rivista
Tipo: Articolo in rivista
Titolo: Age- and gender-dependent association of the -344C/T polymorphism of CYP11B2 with blood pressure in European populations.
Anno di pubblicazione: 2007
Autori: Russo P; Loguercio M; Lauria F; Barba G; Arnout J; Cappuccio FP; Iacoviello L; Siani A.
Affiliazioni autori: Unit of Epidemiology and Population Genetics, Institute of Food Sciences, CNR, Via Roma, 64-83100 Avellino, Italy; Centre for Molecular and Vascular Biology, Katholieke Universiteit Leuven, Leuven, Belgium; Clinical Sciences Research Institute, Warwick Medical School, Coventry, UK Research Laboratories, Centre for High Technology Research and Education in Biomedical Sciences, Catholic University, Campobasso, Italy
Abstract: The -344C/T polymorphism in the 50 promoter region of CYP11B2 has been associated with arterial hypertension and hypertension-related phenotypes with conflicting results, probably attributable to gender-, age-, and ethnicity-related variations in its phenotypic expression. We evaluated the association of -344C/T polymorphism with blood pressure and prevalence of hypertension in a large sample of men and women participating to the IMMIDIET project, a population-based cross-sectional study in three European countries (Italy, UK, Belgium). In this population sample, the C allele of -344C/T was associated with higher blood pressure and prevalence of hypertension in younger men but not in older men and in women, thus, suggesting that this allele may confer increased susceptibility to hypertension early in life.
Lingua abstract: inglese
Pagine da: 333
Pagine a: 336
Journal of human hypertension
Macmillan Press, Scientific & Medical Division,
Numero volume: 21
Referee: Sė: Internazionale
Indicizzato da: ISI Web of Science (WOS) 
Allegati: Articolo pubblicato
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