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Contributo in rivista
Tipo: Articolo in rivista
Titolo: -344C/T variant in the promoter of the aldosterone synthase gene (CYP11B2) is associated with metabolic syndrome in men.
Anno di pubblicazione: 2007
Autori: Russo P; Lauria F; Loguercio M; Barba G; Arnout J; Cappuccio FP; de Lorgeril M; Donati MB; Iacoviello L; Krogh V; van Dongen M; and Siani A, on behalf of the European Collaborative Group of the IMMIDIET Project
Affiliazioni autori: Unit of Epidemiology & Population Genetics, Institute of Food Sciences, CNR, Avellino, Italy; Centre for Molecular and Vascular Biology, Katholieke Universiteit Leuven, Leuven, Belgium; Clinical Sciences Research Institute, Warwick Medical School, Coventry, United Kingdom; Laboratoire Nutrition, Vieillissement et Maladies Cardiovasculaires, UFR de Médécine et Pharmacie, Université Joseph Fourier, Grenoble, France; Centre for High Technology Research and Education in Biomedical Sciences, Catholic University, Campobasso, Italy; Nutritional Epidemiology Unit, National Cancer Institute, Milan, Italy; and Department of Epidemiology, Maastricht University, Maastricht, The Netherlands.
Abstract: BACKGROUND: The -344C/T variant in the promoter of the aldosterone synthase gene (CYP11B2) has been associated with hypertension and may influence glucose homeostasis and body mass in humans. We assessed the association between this genetic variant and metabolic syndrome in a large sample of European population. METHODS: Eight hundred two male/female couples, recruited in the framework of the IMMIDIET study, a survey on cardiovascular risk in Italy, UK, and Belgium, had standardized measurements of body mass index, waist circumference, blood pressure (BP), serum total and HDL-cholesterol, triglycerides, and glucose and were genotyped for the -344C/T variant of CYP11B2. Metabolic syndrome was defined according to the International Diabetes Federation criteria. RESULTS: The prevalence of the metabolic syndrome was 23.9% in men and 14.0% in women. The C allele of the variant was associated with metabolic syndrome in men (P = .002) but not in women. At logistic regression analysis, the odds ratio of metabolic syndrome increased progressively with the number of copies of the C allele (CT: 1.54, 95% CI from 1.01 to 2.35; CC: 2.25, 95% CI from 1.38 to 3.66) as compared with the TT homozygotes, taken as reference genotype. CONCLUSIONS: The C allele of -344C/T variant of CYP11B2 increases susceptibility to metabolic syndrome in European men, but not in women, suggesting a pleiotropic role for this gene in modulating cardiovascular risk.
Lingua abstract: inglese
Pagine da: 218
Pagine a: 222
American journal of hypertension
Nature Publishing Group
Numero volume: 20
Referee: Sě: Internazionale
Indicizzato da: ISI Web of Science (WOS) 
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