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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2007

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Identification of a peptide from a-gliadin resistant to digestive enzymes: implications for celiac disease

Anno di pubblicazione: 2007

Formato: Elettronico Cartaceo

Autori: Mamone G, Ferranti P, Rossi M, Roepstrorff P, Fierro O, Malorni A, Addeo F.

Affiliazioni autori: Proteomic and Biomolecular Mass Spectrometry Centre, Institute of Food Science CNR, Avellino, Italy Department of Food Science, University of Naples ‘Federico II’, Portici (NA), Italy Lab of Immunobiology, Institute of Food Science CNR, Avellino, Italy Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark Lab of Food Chemistry and Technology, Institute of Food Science CNR, Avellino, Italy

Autori CNR:

  • FRANCESCO ADDEO
  • PASQUALE FERRANTI
  • OLGA FIERRO
  • ANTONIO MALORNI
  • GIANFRANCO MAMONE
  • MAURO ROSSI

Lingua: inglese

Abstract: Current knowledge indicates that both innate and adaptive immune responses are involved in Celiac disease (CD) driven by different gliadin peptides. By studying a representative recombinant alpha-gliadin form, a further 25-mer peptide resistant to gastric, pancreatic, and human intestinal brush-border membrane enzymes was detected. This peptide latter encompasses the sequence 31-43 known to elicit the innate immune response in CD. The resistance of 25-mer, as well as that of the already described 33-mer related to the CD adaptive immune response, was confirmed on a standard flour wheat sample representative of the most widespread European varieties.

Lingua abstract: inglese

Pagine da: 236

Pagine a: 241

Rivista:

Journal of chromatography. B Elsevier
Paese di pubblicazione: Paesi Bassi
Lingua: inglese
ISSN: 1570-0232

Numero volume: 855

DOI: 10.1016/j.jchromb.2009.11.033

Referee: Sì: Internazionale

Indicizzato da:

  • ISI Web of Science (WOS) [000249167400016]
  • PubMed [17544966]

Parole chiave:

  • Celiac disease; Gliadin; Brush-border membrane enzymes; Prolamin Working Group standard; Mass spectrometry

Strutture CNR:

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