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Contributo in rivista
Tipo: Articolo in rivista
Titolo: Circulating leptin levels predict the development of metabolic syndrome in middle-aged men: an 8-year follow-up study.
Anno di pubblicazione: 2007
Autori: Galletti F; Barbato A; Versiero M; Iacone R; Russo O; Barba G; Siani A; Cappuccio FP; Farinaro E; della Valle E; Strazzullo P.
Affiliazioni autori: Department of Clinical and Experimental Medicine, Federico II University of Naples Medical School, Naples, Italy, Epidemiology and Population Genetics, Institute of Food Science, CNR, Avellino, Italy, Clinical Sciences Research Institute,Warwick Medical School, Coventry, UK Departments of Preventive Medical Sciences, Federico II University of Naples, Medical School, Naples, Italy
Abstract: BACKGROUND: Because high circulating plasma leptin is associated with many features of the metabolic syndrome (MS), such as abdominal obesity, insulin resistance and high blood pressure (BP), we analysed the ability of plasma leptin concentration to predict the risk of developing MS in a prospective investigation of adult male participants of the Olivetti Heart Study (OHS). METHODS AND RESULTS: Three hundred and sixty out of 907 men participating in the 1994-95 and 2002-04 OHS examinations (mean age at baseline 50.4 years, range 25-73 years) were free of MS at first visit according to NCEP-ATP III criteria (modified for the lack of high-density lipoprotein cholesterol measurement at baseline). During an average follow-up period of 8 years, there were 52 incident cases of MS (14.5%) due, in particular, to a rise in the prevalence of high BP (+42.4%), abdominal obesity (+16.4%) and impaired fasting glucose (IFG, +6.1%). In multivariate analyses, a one standard deviation difference in baseline plasma leptin concentration was associated with a 1.58-fold greater risk of developing MS (95% confidence interval = 1.10-2.30, P = 0.016) accounting for age, waist circumference, homeostatic assessment model index, smoking, alcohol consumption and physical activity. In particular, plasma leptin was positively associated with the risk of developing high BP (0.006) and IFG (0.014), after adjustment for confounders. CONCLUSION: In this sample of an adult male population free of MS at baseline, circulating plasma leptin was a significant predictor of the risk of MS and, in particular, of its high BP and IFG components, independently of potential confounders.
Lingua abstract: inglese
Pagine da: 1671
Pagine a: 1677
Journal of hypertension
Numero volume: 25
Referee: Sė: Internazionale
Indicizzato da: ISI Web of Science (WOS) 
Allegati: Articolo pubblicato
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