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Contributo in rivista
Tipo: Articolo in rivista
Titolo: Incidence of hypertension in individuals with different salt-sensitivity of blood pressure. Results of a 15-year follow-up study.
Anno di pubblicazione: 2007
Autori: Barba G; Galletti F; Cappuccio FP; Siani A; Venezia A; Versiero M; Della Valle E; Sorrentino P; Tarantino G; Farinaro E; and Strazzullo P.
Affiliazioni autori: Epidemiology and Population Genetics, Institute of Food Sciences, CNR, Avellino, Department of Clinical and Experimental Medicine, 'Federico II' University of Naples, Naples, Italy, Division of Clinical Sciences, Clinical Sciences Research Institute, Warwick Medical School, Coventry, UK and Department of Preventive Medical Sciences, 'Federico II' University of Naples, Naples, Italy
Abstract: OBJECTIVE: To evaluate the incidence of hypertension and the rate of decline in renal function in a sample of 47 Olivetti Heart Study (OHS) participants whose blood pressure (BP) salt-sensitivity and renal tubular sodium handling had been assessed in 1987-88. METHODS: During the 2002-04 OHS follow-up examination, medical history, physical examination and blood and urine sampling were performed in 36 of the 47 participants to the baseline study (age 60 +/- 6 years; average follow-up = 15.1 +/- 0.6 years). The renal length was measured in 23 participants by kidney ultrasonography. Based on the baseline salt-sensitivity evaluation, the subjects were classified into a lower salt-sensitivity (LSS, n = 20) and a higher salt-sensitivity group (HSS, n = 16). RESULTS: In comparison with the LSS group, HSS participants had a significantly higher incidence of hypertension (87.5 versus 50.0%, P = 0.02), a higher glomerular filtration rate (median, first to fourth quartile: 81.9, 72.3-95.2 versus 72.3, 59.9-81.2 ml/min; P = 0.03) and greater kidney length (median, first to fourth quartile: 68.2, 63.3-72.1 versus 61.9, 58.7-62.7 mm/m of height; P = 0.003). The incidence of hypertension remained significantly higher in HSS individuals after adjustment for age, intercurrent changes in body mass index and baseline blood pressure on low sodium diet (P = 0.04). CONCLUSION: Our findings indicate that individuals with higher BP salt-sensitivity have a higher rate of incident hypertension and suggest an altered renal tubular sodium handling involving a trend to increased glomerular filtration rate and blood pressure over time as a possible mechanism.
Lingua abstract: inglese
Pagine da: 1465
Pagine a: 1471
Journal of hypertension
Numero volume: 25
Referee: Sė: Internazionale
Indicizzato da: ISI Web of Science (WOS) 
Allegati: Articolo pubblicato
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