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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2006

Contributo in rivista

Tipo: Articolo in rivista

Titolo: HindIII(+/-) Polymorphism of the Y Chromosome, Blood Pressure and Serum Lipids: No Evidence of Association in Three Caucasian Populations.

Anno di pubblicazione: 2006

Autori: Russo P; Venezia A; Lauria F; Strazzullo P; Cappuccio FP; Iacoviello L; Barba G, Siani A.

Affiliazioni autori: Unit of Epidemiology & Population Genetics, Institute of Food Sciences, CNR, Avellino, Italy; Univ. Napoli Federico II; Univ. of Warwick, UK; Univ. Cattolica Sacro Cuore, CB

Autori CNR:

  • GIANVINCENZO BARBA
  • FABIO LAURIA
  • PAOLA RUSSO
  • ALFONSO SIANI

Lingua: inglese

Abstract: BACKGROUND: Male sex is associated with elevated levels of cardiovascular risk factors, including higher blood pressure (BP). Genetic variants on the Y chromosome may contribute to explain the sexual dimorphism in cardiovascular diseases. Among them, the HindIII(+/-) polymorphism of the male-specific region of the Y chromosome has been associated with BP and serum cholesterol levels, with conflicting results. We evaluated the association between the HindIII(+/-) polymorphism, prevalence of hypertension, BP, and serum lipid levels in a large sample of white men and the previously reported epistatic interaction between HindIII(+/-) and the -344C/T polymorphism of the aldosterone synthase gene (CYP11B2) on BP. METHODS: From three European populations (UK n = 422; Belgium n = 313; Italy n = 1248) 1983 white men were phenotyped for BP and serum lipids and genotyped for HindIII(+/-) site and for -344C/T polymorphism in the promoter of CYP11B2 by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). RESULTS: A higher frequency of the HindIII (+) was found in Italians (63%) as compared to both British (31%) and Belgians (28%) (P < .0001). We found no evidence of association of the HindIII(+/-) site with prevalence of hypertension, BP, and serum lipids in any of the three European populations examined and in the entire sample. Finally, we did not observe any interaction between the HindIII(+/-) polymorphism and the -344C/T variant of CYP11B2 on BP. CONCLUSIONS: Our data do not support the hypothesis that the HindIII(+/-) site of the Y chromosome is a marker of cardiovascular risk in white men, highlighting the need for replication in genetic association studies.

Lingua abstract: inglese

Pagine da: 331

Pagine a: 338

Rivista:

American journal of hypertension Nature Publishing Group
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 0895-7061

Numero volume: 19

DOI: 10.1016/j.amjhyper.2005.10.003

Referee: Sė: Internazionale

Indicizzato da: ISI Web of Science (WOS) [000236621400001]

Parole chiave:

  • Y chromosome
  • blood pressure
  • lipids
  • cardiovascular diseases
  • genetic association

Strutture CNR:

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Allegati: Articolo pubblicato (application/pdf)

 
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