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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2006

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Cervical fetal fibronectin as a predictor of first trimestre pregnancy outcome in unexplained recurrent miscarriage.

Anno di pubblicazione: 2006

Formato: Elettronico

Autori: Mercorio F, Mercorio A, Di Spezio Sardo A, Votino C, Barba G, Nappi C.

Affiliazioni autori: Mercorio Francesco, Department of Gynecology and Obsterics, and Pathophysiology of Human Reproduction, University of Naples ''Federico II'' Mercorio Antonio, Department of Obstetrics and Gynecology, University of Foggia, Italy Di Spezio Sardo Attilio, Department of Gynecology and Obsterics, and Pathophysiology of Human Reproduction, University of Naples ''Federico II'' Votino Carmela, Department of Gynecology and Obsterics, and Pathophysiology of Human Reproduction, University of Naples ''Federico II'' Nappi Carmine, Department of Gynecology and Obsterics, and Pathophysiology of Human Reproduction, University of Naples ''Federico II''

Autori CNR:

  • GIANVINCENZO BARBA

Lingua: inglese

Abstract: OBJECTIVE: To determine whether cervical fetal fibronectin is a reliable predictor of first trimester pregnancy outcome in patients with unexplained recurrent miscarriage. STUDY DESIGN: A prospective observational study was carried out on 49 pregnant women with a history of unexplained recurrent miscarriage. In all participants the presence of fetal fibronectin in the cervical secretion was determined with a qualitative rapid immunoassay. The outcome of the first trimester pregnancy was recorded a successful outcome was a pregnancy that progressed beyond 12 weeks of gestation; a miscarriage referred to a pregnancy loss in the first 12 weeks. RESULTS: Of the 49 subjects screened, fetal fibronectin was positive in 17 and negative in 32. Overall, 14 pregnancies resulted in fetal loss before the 12th week of gestation. Fetal cervical fibronectin was positive in 6 of the 14 patients who miscarried and in 11 of the 35 in whom outcome was successful. As predictor of first trimester pregnancy outcome the test had a sensitivity and a specificity of 43% and 69% and positive and negative predictive values of 35%, and 75%, respectively. Subgroup analysis by number of previous miscarriages and maternal age gave similar values. CONCLUSION: This study examines the possible value of cervical fetal fibronectin in predicting first trimester pregnancy outcome. We conclude that the occurrence of positive or negative fetal cervical fibronectin test has only limited predictive value and therefore its use cannot be considered for clinical application.

Lingua abstract: inglese

Pagine da: 165

Pagine a: 169

Rivista:

European journal of gynaecological oncology SOG Canada.
Paese di pubblicazione: Canada
Lingua: inglese
ISSN: 0392-2936

Numero volume: 126

DOI: 10.1016/j.ejogrb.2005.08.007

Referee: Sė: Internazionale

Indicizzato da: PubMed [PMID: 16256259]

Parole chiave:

  • Cervical fetal fibronectin
  • Unexplained recurrent miscarriage
  • First trimester pregnancy outcome

URL: http://www.ncbi.nlm.nih.gov/pubmed/16256259

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