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Contributo in rivista
Tipo: Articolo in rivista
Titolo: Interactive effects of fumonisin B1 and a-zearalenol on proliferation and cytokine expression in Jurkat T cells.
Anno di pubblicazione: 2006
Formato: Elettronico Cartaceo
Autori: Luongo D; Severino L; Bergamo P; De Luna R; Lucisano A; Rossi M.
Affiliazioni autori: Department of Pathology and Animal Health -Division of Toxicology- University of Naples "Federico II", via Delpino 1, 80137 Naples, Italy. Istituto di Scienze dell'Alimentazione, CNR
Abstract: Mycotoxins are secondary metabolites of fungi that grow on various food and feed. These compounds elicit a wide spectrum of toxicological effects, including the capacity to alter normal immune function. Feed commodities are usually contaminated with more than one mycotoxin; however, extensive information on the interaction between concomitantly occurring mycotoxins and the consequence for their toxicity is lacking. In the present study, we examined the effects in vitro of fumonisin B1 (FB1) and alpha-zearalenol (alpha-ZEA), alone or in combination, on the immune function in the human lymphoblastoid Jurkat T cell line. Treatment of cells with increasing concentrations of FB1 resulted in a dose-dependent induction of proliferation. In contrast, alpha-ZEA showed a marked inhibitory effect on cell proliferation, even at very low doses, essentially mediated by apoptosis. In stimulated cells pre-incubated with FB1, the levels of IL-2 and IFN gamma mRNAs were similar to control whereas a reduction of cytokine transcripts was reported following alpha-ZEA treatment. Interestingly, co-administration of mycotoxins resulted in further inhibition of both proliferation and IFN gamma mRNA expression when compared with alpha-ZEA alone. In conclusion, FB1 and alpha-ZEA showed different immunomodulation abilities when individually administered. Combination of mycotoxins resulted instead in interactive effects.
Lingua abstract: inglese
Pagine da: 1403
Pagine a: 1410
Toxicology in vitro
Numero volume: 20
Numero fascicolo: 8
Indicizzato da: ISI Web of Science (WOS) 
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