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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2005

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Fetal febronectin as predictor of successful induction of mid-trimester abortion.

Anno di pubblicazione: 2005

Formato: Elettronico

Autori: Mercorio F., Mercorio A., Votino C., Di Spezio Sardo A., Barba G., Nappi C.

Affiliazioni autori: MERCORIO Francesco, Department of Gynecology and Obstetrics, and Pathophysiology of Human Reproduction, University of Naples ''Federico II'' MERCORIO Antonio, Department of Obstetrics and Gynecology, University of Foggia VOTINO Carmela, Department of Gynecology and Obstetrics, and Pathophysiology of Human Reproduction, University of Naples ''Federico II'' DI SPIEZIO SARDO Attilio, Department of Gynecology and Obstetrics, and Pathophysiology of Human Reproduction, University of Naples ''Federico II'' NAPPI Carmine, Department of Gynecology and Obstetrics, and Pathophysiology of Human Reproduction, University of Naples ''Federico II''

Autori CNR:

  • GIANVINCENZO BARBA

Lingua: inglese

Abstract: BACKGROUND: Fetal fibronectin (FFN) in cervical secretion is one of the most effective markers of pre-term and term delivery. The presence of FFN in cervicovaginal secretions has recently been shown to reflect cervical state and an uncomplicated induction of labor at term. This study was designed to determine whether FFN could be a biochemical marker to predict the response to prostaglandins in early mid-trimester abortion. METHODS: The presence of cervical FFN was evaluated by means of qualitative rapid immunoassay in 270 patients, who required second trimester termination of pregnancy at the Department of Gynecology and Obstetrics, University of Naples 'Federico II'. According to the standard protocol of our unit, women received 1.0 mg of gemeprost intravaginally at 3-hr intervals up to a maximum of five suppositories. The induction-to-abortion interval and the percentage of successful abortions within 24 hr in women in the positive FFN group (n=19) were compared with those in the negative FFN group (n=251). RESULTS: FFN in the cervical secretions was present in seven women (10.2%) at 16-weeks gestation, in seven women (7.5%) at 17-weeks gestation, and in five women (4.5%) at 18-week gestation. Final termination rates were 13 (68.4%) in the fibronectin-positive group and 177 (70.5%) in the fibronectin-negative group. The median abortion interval was similar (14.7 versus 15.1 hr) in both groups. CONCLUSIONS: A positive cervical fetal fibronectin test does not predict a successful medical termination of pregnancy in second trimester abortion. In this setting, the role of fetal cervical fibronectin in cervical ripening is, therefore, questionable.

Lingua abstract: inglese medio (1100-1500)

Pagine da: 390

Pagine a: 394

Pagine totali: 5

Rivista:

Acta obstetricia et gynecologica Scandinavica Munksgaard International Publishers.
Paese di pubblicazione: Danimarca
Lingua: inglese
ISSN: 0001-6349

Numero volume: 84

DOI: 10.1111/j.0001-6349.2005.00675.x

Referee: Sė: Internazionale

Parole chiave:

  • cervical secretion; fetal fibronectin; midtrimester abortion

URL: http://onlinelibrary.wiley.com/doi/10.1111/j.0001-6349.2005.00675.x/full

Altre informazioni: 2

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