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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2005

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Small intestinal enteropathy in non-obese diabetic mice fed a diet containing wheat.

Anno di pubblicazione: 2005

Autori: Maurano F., Mazzarella G., Luongo D., Stefanile R., D'Arienzo R., Rossi M., Auricchio S., Troncone R.

Affiliazioni autori: Istituto di Scienze dell'Alimentazione, CNR, Avellino, Italia Department of Pediatrics, European Laboratory for the Investigation of Food Induced Diseases-ELFID, University Federico II, Naples, Italy.

Autori CNR:

  • ROSSANA D'ARIENZO
  • DIOMIRA LUONGO
  • FRANCESCO MAURANO
  • GIUSEPPE MAZZARELLA
  • MAURO ROSSI

Lingua: inglese

Abstract: AIMS/HYPOTHESIS: A deranged mucosal immune response and dietary factors may play an important role in the pathogenesis of type 1 diabetes. The aims of our work were to look for the presence of small intestinal enteropathy in non-obese diabetic (NOD) mice in relation to the presence of wheat proteins in the diet, and to assess their role in the risk of developing diabetes. METHODS: Female NOD mice were fed a standard or gluten-free diet or a gluten-free diet with the addition of wheat proteins (MGFD). Small intestine architecture, intraepithelial CD3(+) infiltration, epithelial expression of H2-IA, mRNA for IFN-gamma and IL-4 were assessed. RESULTS: NOD mice fed a standard diet showed reduced villous height, increased intraepithelial infiltration by CD3(+) cells and enhanced expression of H2-IA and IFN-gamma mRNA when compared with mice on the gluten-free diet. The cumulative diabetes incidence at 43 weeks of age was 65% in the latter and 97% in the former (p<0.01). Mice on MGFD also showed increased epithelial infiltration and a higher incidence of diabetes. CONCLUSIONS/INTERPRETATION: Mice fed a wheat-containing diet showed a higher incidence of diabetes, signs of small intestinal enteropathy and higher mucosal levels of proinflammatory cytokines.

Pagine da: 931

Pagine a: 937

Rivista:

Diabetologia Springer .
Paese di pubblicazione: Germania
Lingua: inglese
ISSN: 0012-186X

Numero volume: 48

DOI: 10.1007/s00125-005-1718-2

Indicizzato da: ISI Web of Science (WOS) [WOS:000229095200019]

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