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Contributo in rivista
Tipo: Articolo in rivista
Titolo: Small intestinal enteropathy in non-obese diabetic mice fed a diet containing wheat.
Anno di pubblicazione: 2005
Autori: Maurano F., Mazzarella G., Luongo D., Stefanile R., D'Arienzo R., Rossi M., Auricchio S., Troncone R.
Affiliazioni autori: Istituto di Scienze dell'Alimentazione, CNR, Avellino, Italia Department of Pediatrics, European Laboratory for the Investigation of Food Induced Diseases-ELFID, University Federico II, Naples, Italy.
Abstract: AIMS/HYPOTHESIS: A deranged mucosal immune response and dietary factors may play an important role in the pathogenesis of type 1 diabetes. The aims of our work were to look for the presence of small intestinal enteropathy in non-obese diabetic (NOD) mice in relation to the presence of wheat proteins in the diet, and to assess their role in the risk of developing diabetes. METHODS: Female NOD mice were fed a standard or gluten-free diet or a gluten-free diet with the addition of wheat proteins (MGFD). Small intestine architecture, intraepithelial CD3(+) infiltration, epithelial expression of H2-IA, mRNA for IFN-gamma and IL-4 were assessed. RESULTS: NOD mice fed a standard diet showed reduced villous height, increased intraepithelial infiltration by CD3(+) cells and enhanced expression of H2-IA and IFN-gamma mRNA when compared with mice on the gluten-free diet. The cumulative diabetes incidence at 43 weeks of age was 65% in the latter and 97% in the former (p<0.01). Mice on MGFD also showed increased epithelial infiltration and a higher incidence of diabetes. CONCLUSIONS/INTERPRETATION: Mice fed a wheat-containing diet showed a higher incidence of diabetes, signs of small intestinal enteropathy and higher mucosal levels of proinflammatory cytokines.
Pagine da: 931
Pagine a: 937
Numero volume: 48
Indicizzato da: ISI Web of Science (WOS) [WOS:000229095200019]
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