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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2004

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Casein proteolysis in human milk: tracing the pattern of casein breakdown and the formation of potential bioactive peptides

Anno di pubblicazione: 2004

Autori: Ferranti P, Traisci MV, Picariello G, Nasi A, Boschi V, Siervo M, Falconi C, Chianese L, Addeo F.

Autori CNR:

  • FRANCESCO ADDEO
  • PASQUALE FERRANTI
  • GIANLUCA PICARIELLO

Abstract: The protein and peptide fraction of human milk samples collected from mothers of pre- and full-term infants in the first week after parturition was analysed by use of liquid chromatography-mass spectrometry and tandem mass spectrometry. By characterising the peptide sequence, we defined the pathway of casein hydrolysis which leads to the formation of small peptides through intermediate oligopeptides. It was found that the action of a plasmin-like enzyme acting on specific lysine residues is the primary step in casein degradation. This is followed by endopeptidases and/or exopeptidases mediated cleavage of the oligopeptides which, in turn, produces a multiplicity of short peptides differing by one or more amino acid residues. In this process, a series of potentially bioactive peptides (opioid, phosphopeptides) and their precursors are produced.

Pagine da: 74

Pagine a: 87

Rivista:

Journal of dairy research Empire Marketing Board, Dairy Research Committee,
Paese di pubblicazione: Regno Unito
Lingua: inglese
ISSN: 0022-0299

Numero volume: 71(1)

Altre informazioni: 7

Strutture CNR:

 
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