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Contributo in rivista
Tipo: Articolo in rivista
Titolo: Aldosterone synthase gene (CYP11B2) C-344T polymorphism, plasma aldosterone, renin activity and blood pressure in a multi-ethnic population.
Anno di pubblicazione: 2004
Autori: Barbato A; Russo P; Siani A; Folkerd EJ; Miller MA; Venezia A; Grimaldi C; Strazzullo P; Cappuccio FP.
Affiliazioni autori: Unit of Epidemiology and Population Genetics, Institute of Food Sciences, CNR, Via Roma, 64-83100 Avellino, Italy; Department of Community Health Sciences, St George's Hospital Medical School, London, UK, Department of Clinical & Experimental Medicine, Federico II Medical School, University of Naples, Italy.
Abstract: BACKGROUND: The aldosterone synthase gene (CYP1B2) locus is a candidate region involved in the development of hypertension. OBJECTIVE: To study the relationship between the C-344T CYP1B2 polymorphism, plasma aldosterone, renin activity and blood pressure in a multi-ethnic population. DESIGN: Population-based, cross-sectional study of 1313 middle-aged men and women (456 white, 441 of African origin and 416 South Asian). Anthropometry, blood pressure, biochemistry, questionnaire data and timed urine collections were taken with standardized techniques. All were genotyped for the C-344T CYP11B2 polymorphism. RESULTS: The frequency of the C allele was significantly lower in people of African origin (0.21) than in white (0.46) and South Asian (0.43) (P < 0.001). After adjustment for age, sex and ethnicity the TT genotype was associated with 14% higher plasma aldosterone levels, 3.7 mmHg higher systolic and 2.1 mmHg higher diastolic blood pressure than CC (P for linear trend < 0.05). No significant interactions with age, sex, ethnicity, body mass index (BMI) and fractional excretion of sodium were found in the associations between genotype and both blood pressure and aldosterone levels. In a sub-sample of participants in which plasma renin activity was measured (n = 457), a significant excess of T alleles was found in those with a raised (>/= 750) aldosterone-to-renin ratio (ARR). CONCLUSION: In this multi-ethnic population, the C-344T CYP1B2 polymorphism is associated with blood pressure, plasma aldosterone levels and ARR. Although significant differences in allele frequencies were found between groups, ethnicity does not explain the results.
Lingua abstract: inglese
Pagine da: 1895
Pagine a: 1901
Journal of hypertension
Numero volume: 22
Referee: Sė: Internazionale
Indicizzato da: ISI Web of Science (WOS) 
Altre informazioni: A Barbato and P Russo contributed equally to the study.
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