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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2002

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Interaction between the C(-344)T polymorphism of CYP11B2 and age in the regulation of blood pressure and plasma aldosterone levels: cross-sectional and longitudinal findings of the Olivetti Prospective Heart Study

Anno di pubblicazione: 2002

Formato: Elettronico Cartaceo

Autori: Russo P., Siani A., Venezia A., Iacone R., Russo O., Barba G., D'Elia L., Cappuccio F., Strazzullo P.

Affiliazioni autori: Russo P., Siani A., Venezia A., Barba G. Istituto di Scienze dell'Alimentazione, CNR, Avellino; Iacone R., Russo O., D'Elia L., Cappuccio F., Strazzullo P. Dip. Medicina Clinica e Sperimentale, Università Federico II di Napoli

Autori CNR:

  • GIANVINCENZO BARBA
  • PAOLA RUSSO
  • ALFONSO SIANI

Lingua: inglese

Abstract: OBJECTIVE: To study the interaction between the C(-344)T polymorphism and known determinants (age, body mass and dietary sodium) of blood pressure and plasma aldosterone. DESIGN: Cross-sectional and longitudinal 1980-1995) survey of male workers in southern Italy. SETTING: Medical centre of the Olivetti factories. PARTICIPANTS: In 1995, the C(-344)T polymorphism was characterized in 811 untreated men. A subgroup of 280 participants already seen in 1980 was the object of longitudinal analysis. MAIN OUTCOME MEASURES: Blood pressure, demographic, anthropometric and biochemical variables (serum and urinary electrolytes and plasma aldosterone) and frequency of the C(-344)T polymorphism. RESULTS: In the whole population, there was no difference among genotypes for any of the variables examined. However, multiple regression showed a significant interaction between age (but not body mass or sodium intake) and genotype with regard to systolic (P = 0.03) and diastolic ( P= 0.02) pressure variability independently of covariates. Diastolic pressure increased linearly with age in carriers of the T allele (TT, P<0.001 and TC, P= 0.005), but not in CC homozygotes ( P= 0.848). In T carriers - but not in CC homozygotes - blood pressure and serum potassium increased and plasma aldosterone and serum sodium decreased across quintiles of age (P<0.001 for all trends). In the longitudinal study, diastolic pressure increased significantly over time only in T carriers(TC+TT: +2.6 +/- 0.6, versus CC: -0.4 +/- 1.5 mmHg, P= 0.04). CONCLUSION: Inter-individual variation of blood pressure and plasma aldosterone is affected by the interaction of C(-344)T polymorphism and ageing, thus supporting a role for this variant in mechanisms affecting blood pressure regulation.

Pagine da: 1785

Pagine a: 1792

Rivista:

Journal of hypertension Gower Medical,
Paese di pubblicazione: Regno Unito
Lingua: inglese
ISSN: 0263-6352

Numero volume: 20

Referee: Sì: Internazionale

Indicizzato da: PubMed [12195120]

Parole chiave:

  • genetica
  • epidemiologia
  • rischio cardiovascolare

Altre informazioni: Fattore d'impatto 2003: 3.572

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Allegati: articolo pubblicato (application/pdf)

 
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