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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2003

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Altered renal handling of sodium in human hypertension: short review of the evidence

Anno di pubblicazione: 2003

Formato: Elettronico Cartaceo

Autori: Strazzullo P, Galletti F, Barba G.

Affiliazioni autori: Istituto di Scienze dell'Alimentazione, CNR, Avellino; Università di Napoli Federico II

Autori CNR:


Lingua: inglese

Abstract: A pathogenic role of the kidney in hypertension has been strongly supported by experimental studies by Guyton and Dahl since the 1960s. In the early 1980s, de Wardener and MacGregor proposed that in hypertensive patients the ability of the kidneys to excrete a sodium load could be genetically impaired. Since then, "sodium-sensitive" hypertension has been the object of numerous studies, mostly on animal models because of the difficulty to investigate the renal handling of sodium in humans. More recently, considerable progress in this field has been made thanks to the in vivo study of segmental renal tubular function by the clearance of lithium and to the growing knowledge of the genetics of renal tubular sodium transport systems. The scope of this review is to briefly review the most relevant information gathered by the investigation of segmental renal tubular sodium handling in humans as related to blood pressure regulation and hypertension. In aggregate, the results of these studies strongly support the association between altered renal sodium handling and high blood pressure and suggest a causal role of genetic, nutritional, metabolic, and neurohormonal factors. All of these factors, alone or in combination, may be able to impair the normal renal tubular sodium handling and influence blood pressure homeostasis. The paradigm of the pathogenic role of the kidney in hypertension is thus relentlessly shifting toward the definition of inherited as well as acquired renal tubular defects and molecular alterations, providing a plausible explanation for the alteration in blood pressure levels.

Lingua abstract: inglese

Pagine da: 1000

Pagine a: 1005


Hypertension American Heart Association,
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 0194-911X

Numero volume: 41

DOI: 10.1161/01.HYP.0000066844.63035.3A

Referee: Sì: Internazionale

Indicizzato da: PubMed [12668589]

Parole chiave:

  • funzione renale
  • sodio
  • malattie cardiovascolari
  • review

Strutture CNR:


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