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Contributo in rivista
Tipo: Articolo in rivista
Titolo: Antimalarial and antiproliferative evaluation of bis-steroidal tetraoxanes
Anno di pubblicazione: 2003
Autori: Opsenica D, Angelovski G, Pocsfalvi G, Juranic Z, Zizak Z, Kyle D, Milhous WK, Solaja BA.
Abstract: Several cis and trans bis-steroidal 1,2,4,5-tetraoxanes possessing amide terminus were synthesised and evaluated as antimalarials and antiproliferatives. The compounds exhibited submicromolar antimalarial activity against Plasmodium falciparum D6 and W2 strains. The existence of HN-C(O) moiety was found necessary for pronounced antimalarial and antiproliferative activity. In antiproliferative screen, the trans tetraoxane 6 was found to exhibit a pronounced cytotoxicity on 14 cancer cell lines. In addition, tetraoxanes 11 and 12 exhibited significant cytotoxic activity too; microscopic examination of treated HeLa cells showed morphological appearance reminiscent for apoptosis (condensed and/or fragmented nuclei).
Pagine da: 2761
Pagine a: 2768
Bioorganic & medicinal chemistry
Numero volume: 11
Altre informazioni: 4
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