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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2003

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Antimalarial and antiproliferative evaluation of bis-steroidal tetraoxanes

Anno di pubblicazione: 2003

Autori: Opsenica D, Angelovski G, Pocsfalvi G, Juranic Z, Zizak Z, Kyle D, Milhous WK, Solaja BA.

Autori CNR:

  • GABRIELLA KATALIN POCSFALVI

Abstract: Several cis and trans bis-steroidal 1,2,4,5-tetraoxanes possessing amide terminus were synthesised and evaluated as antimalarials and antiproliferatives. The compounds exhibited submicromolar antimalarial activity against Plasmodium falciparum D6 and W2 strains. The existence of HN-C(O) moiety was found necessary for pronounced antimalarial and antiproliferative activity. In antiproliferative screen, the trans tetraoxane 6 was found to exhibit a pronounced cytotoxicity on 14 cancer cell lines. In addition, tetraoxanes 11 and 12 exhibited significant cytotoxic activity too; microscopic examination of treated HeLa cells showed morphological appearance reminiscent for apoptosis (condensed and/or fragmented nuclei).

Pagine da: 2761

Pagine a: 2768

Rivista:

Bioorganic & medicinal chemistry Pergamon,
Paese di pubblicazione: Regno Unito
Lingua: inglese
ISSN: 0968-0896

Numero volume: 11

Altre informazioni: 4

Strutture CNR:

 
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